Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma.

M. Okazaki, H. Kitani, T. Mifune, Fumihiro Mitsunobu, N. Asaumi, Y. Tanizaki, H. Harada, K. Takahashi, I. Kimura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalActa Medica Okayama
Volume45
Issue number4
Publication statusPublished - Aug 1991

Fingerprint

Pyroglyphidae
Immunoglobulin E
Dust
Asthma
Immunoglobulin G
Antibodies
Mites
Immunotherapy
Blocking Antibodies
Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Okazaki, M., Kitani, H., Mifune, T., Mitsunobu, F., Asaumi, N., Tanizaki, Y., ... Kimura, I. (1991). Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma. Acta Medica Okayama, 45(4), 267-273.

Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma. / Okazaki, M.; Kitani, H.; Mifune, T.; Mitsunobu, Fumihiro; Asaumi, N.; Tanizaki, Y.; Harada, H.; Takahashi, K.; Kimura, I.

In: Acta Medica Okayama, Vol. 45, No. 4, 08.1991, p. 267-273.

Research output: Contribution to journalArticle

Okazaki, M, Kitani, H, Mifune, T, Mitsunobu, F, Asaumi, N, Tanizaki, Y, Harada, H, Takahashi, K & Kimura, I 1991, 'Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma.', Acta Medica Okayama, vol. 45, no. 4, pp. 267-273.
Okazaki, M. ; Kitani, H. ; Mifune, T. ; Mitsunobu, Fumihiro ; Asaumi, N. ; Tanizaki, Y. ; Harada, H. ; Takahashi, K. ; Kimura, I. / Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma. In: Acta Medica Okayama. 1991 ; Vol. 45, No. 4. pp. 267-273.
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