Specific antiviral effect of violaceoid E on bovine leukemia virus

Hironobu Murakami, Makoto Murakami-Kawai, Shinji Kamisuki, Shibasaki Hisanobu, Yukine Tsurukawa, Jumpei Uchiyama, Masahiro Sakaguchi, Kenji Tsukamoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Bovine leukemia virus (BLV) infection has spread worldwide causing significant economic losses in the livestock industry. In countries with a high prevalence of BLV, minimizing economic losses is challenging; thus, research into various countermeasures is important for improving BLV control. Because anti-BLV drugs have not been developed, the present study explored a promising chemical compound with anti-BLV activity. Initially, screening of a chemical compound library revealed that violaceoid E (vioE), which is isolated from fungus, showed antiviral activity. Further analysis demonstrated that the antiviral effect of vioE inhibited transcriptional activation of BLV. Cellular thermal shift assay and pulldown assays provided evidence for a direct interaction between vioE and the viral transactivator protein, Tax. These data indicate that interference with Tax-dependent transcription could be a novel target for development of anti-BLV drugs. Therefore, it is suggested that vioE is a novel antiviral compound against BLV.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalVirology
Volume562
DOIs
Publication statusPublished - Oct 2021
Externally publishedYes

Keywords

  • Antiviral activity
  • Antiviral drugs
  • Bovine leukemia virus
  • Chemical compound
  • Tax protein
  • Transcription
  • Violaceoid E

ASJC Scopus subject areas

  • Virology

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