Species-specific alteration of hepatic glucose 6-phosphate dehydrogenase activity with coplanar polychlorinated biphenyl: Evidence for an Ah-receptor-linked mechanism

Miho Hori, Hiroshi Kondo, Noritaka Ariyoshi, Hideyuki Yamada, Kazuta Oguri

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We examined the in vivo effect of a highly toxic coplanar polychlorinated biphenyl (PCB) on the hepatic activity of glucose 6-phosphate dehydrogenase (G6PDH) in aryl hydrocarbon (Ah)-responsive (C57/BL) and -less-responsive (DBA) strains of mice. The activity in the C57BL strain was moderately increased by 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in a dose dependent manner. However, this was not observed in DBA mice although greater doses were injected. 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) with a non-planar structure did not increase G6PDH activity. The increase in G6PDH activity with PCB 126 was also seen in rats, but not in guinea pigs. The activity in the latter species was decreased rather than increased. These results suggest that the induction of hepatic G6PDH by coplanar PCB is mediated by a mechanism involving the Ah receptor, and the response was highly species-specific.

Original languageEnglish
Pages (from-to)951-958
Number of pages8
JournalChemosphere
Volume35
Issue number5
DOIs
Publication statusPublished - Sep 1 1997
Externally publishedYes

Keywords

  • 3,3',4,4',5-pentachlorobiphenyl (PCB 126)
  • Arylhydrocarbon receptor
  • C57BL mice
  • DBA mice
  • Enzyme induction
  • Glucose 6-phosphate dehydrogenase

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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