Spatial relationship between fast and slow components of ictal activities and interictal epileptiform discharges in epileptic spasms

Tomoyuki Akiyama, Mari Akiyama, Katsuhiro Kobayashi, Tohru Okanishi, Cyrus G. Boelman, Dragos A. Nita, Ayako Ochi, Cristina Y. Go, O. Carter Snead, James T. Rutka, James M. Drake, Sylvester Chuang, Hiroshi Otsubo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: We analyzed the spatial distribution and concordance of fast (>10. Hz) and slow (<5. Hz) electroencephalogram (EEG) components of ictal activities and interictal epileptiform discharges (IIED) recorded by intracranial video EEG (IVEEG) in children with epileptic spasms (ES). Methods: We studied eight children with ES, who underwent IVEEG before resective surgery for epilepsy. We quantified the root-mean-square (RMS) amplitude of the fast and slow components of ictal activities during ES and IIED. We compared the concordance between the spatial distributions of the fast and slow components of ES and IIED. Results: There was a larger concordance between the spatial distributions of the fast and slow components in IIED than in ES (p= 0.0206 and 0.0401). Conclusions: The spatial concordance between the fast and slow EEG components was significantly different between ES and IIED. Significance: The mechanisms underlying the generation of slow EEG components may differ between ES and IIED. The slow EEG components of ES might indicate an extensive epileptic network involving remote symptomatic zones for ES in either the cortical or subcortical areas. The high spatial concordance between the fast and slow components of IIED suggests the involvement of a local inhibitory process within the epileptic cortex.

Original languageEnglish
Pages (from-to)1684-1691
Number of pages8
JournalClinical Neurophysiology
Volume126
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Epileptic spasms
  • Fast waves
  • Interictal epileptiform discharges
  • Slow waves
  • Spatial distribution

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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    Akiyama, T., Akiyama, M., Kobayashi, K., Okanishi, T., Boelman, C. G., Nita, D. A., Ochi, A., Go, C. Y., Snead, O. C., Rutka, J. T., Drake, J. M., Chuang, S., & Otsubo, H. (2015). Spatial relationship between fast and slow components of ictal activities and interictal epileptiform discharges in epileptic spasms. Clinical Neurophysiology, 126(9), 1684-1691. https://doi.org/10.1016/j.clinph.2014.12.005