Spastic paraplegia accompanied by extrapyramidal sign and frontal cognitive dysfunction

Ryo Sasaki, Yasuyuki Ohta, Kota Sato, Koh Tadokoro, Yoshiaki Takahashi, Jingwei Shang, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Hiroyuki Ishiura, Shoji Tsuji, Koji Abe

Research output: Contribution to journalArticle

Abstract

A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on 99mTc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging.

Original languageEnglish
Pages (from-to)3163-3165
Number of pages3
JournalInternal Medicine
Volume58
Issue number21
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Paraplegia
Abnormal Reflexes
Functional Neuroimaging
Muscle Spasticity
Putamen
Frontal Lobe
Single-Photon Emission-Computed Tomography
Upper Extremity
Paralysis
Neurodegenerative Diseases
Lower Extremity
Neck
Extremities
Cognitive Dysfunction
technetium Tc 99m bicisate

Keywords

  • Extrapyramidal sign
  • Frontal cognitive dysfunction
  • Spastic paraplegia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Spastic paraplegia accompanied by extrapyramidal sign and frontal cognitive dysfunction. / Sasaki, Ryo; Ohta, Yasuyuki; Sato, Kota; Tadokoro, Koh; Takahashi, Yoshiaki; Shang, Jingwei; Takemoto, Mami; Hishikawa, Nozomi; Yamashita, Toru; Ishiura, Hiroyuki; Tsuji, Shoji; Abe, Koji.

In: Internal Medicine, Vol. 58, No. 21, 01.01.2019, p. 3163-3165.

Research output: Contribution to journalArticle

Sasaki, Ryo ; Ohta, Yasuyuki ; Sato, Kota ; Tadokoro, Koh ; Takahashi, Yoshiaki ; Shang, Jingwei ; Takemoto, Mami ; Hishikawa, Nozomi ; Yamashita, Toru ; Ishiura, Hiroyuki ; Tsuji, Shoji ; Abe, Koji. / Spastic paraplegia accompanied by extrapyramidal sign and frontal cognitive dysfunction. In: Internal Medicine. 2019 ; Vol. 58, No. 21. pp. 3163-3165.
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