SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion

Hongyun Wang, Irwin Leav, Soichiro Ibaragi, Michael Wegner, Guo Fu Hu, Michael L. Lu, Steven P. Balk, Xin Yuan

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

SOX9 is a transcription factor that plays a critical role in the development of multiple tissues. We previously reported that SOX9 in normal human adult prostate was restricted to basal epithelium. SOX9 was also expressed in a subset of prostate cancer (PCa) cells and was increased in relapsed hormone-refractory PCa. Moreover, SOX9 expression in PCa cell lines enhanced tumor cell proliferation and was β-catenin regulated. Here we report additional in vivo results showing that SOX9 is highly expressed during fetal prostate development by epithelial cells expanding into the mesenchyme, suggesting it may contribute to invasive growth in PCa. Indeed, SOX9 overexpression in LNCaP PCa xenografts enhanced growth, angiogenesis, and invasion. Conversely, short hairpin RNA-mediated SOX9 suppression inhibited the growth of CWR22Rv1 PCa xenografts. These results support important functions of SOX9 in both the development and maintenance of normal prostate, and indicate that these functions contribute to PCa tumor growth and invasion.

Original languageEnglish
Pages (from-to)1625-1630
Number of pages6
JournalCancer Research
Volume68
Issue number6
DOIs
Publication statusPublished - Mar 15 2008

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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