Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction

Tatsuki Honami, Tsuyoshi Shimo, Tatsuo Okui, Naito Kurio, Nur Mohammad Monsur Hassan, Masahiro Iwamoto, Akira Sasaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Sonic hedgehog (Shh) and its signaling have been identified in several human cancers, and increased levels of its expression appear to correlate with disease progression and metastasis. However, the role of Shh in bone destruction associated with oral squamous cell carcinomas, which frequently invade the maxilla or the mandible, is still unclear. In this study we show that the use of siRNA for Shh to block SHH secreted by SAS oral squamous cell carcinoma cells suppressed the tumor growth and tumor angiogenesis of subcutaneous SAS xenografts in vivo. Moreover, blockade of Shh in SAS cells decreased tumor growth and osteoclast number in a tibial metaphysis mouse model. Significantly, we clearly show that SHH stimulated osteoclast formation in a co-culture system consisting of murine bone stromal ST2 cells and murine CD11b + bone marrow cells. These findings suggest that Shh signaling is a potential target for the treatment of oral squamous cell carcinoma associated with bone destruction.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalOral Oncology
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

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Keywords

  • Bone destruction
  • Oral squamous cell carcinoma
  • Osteoclast
  • Sonic hedgehog

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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