Solvent-free formation of hydroxyapatite coated biodegradable particles via nanoparticle-stabilized emulsion route

Masahiro Okada, Syuji Fujii, Taiki Nishimura, Yoshinobu Nakamura, Shoji Takeda, Tsutomu Furuzono

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Hydroxyapatite (HAp) nanoparticle-coated biodegradable polymer particles were fabricated from a nanoparticle-stabilized emulsion in the absence of any molecular surfactants or organic solvents. First, a polymer melt-in-water emulsion was prepared by mixing a water phase containing nanosized HAp particles as a particulate emulsifier and an oil phase consisting of poly(ε- caprolactone) (PCL) or poly(l-lactide-co-ε-caprolactone) (P(LLA-CL)) above its melting point. It was clarified that the interaction between ester/carboxyl groups of the polymers and the HAp nanoparticles at the polymer-water interface played a crucial role to prepare the nanoparticle-stabilized emulsion. The HAp nanoparticle-coated biodegradable polymer particle (a polymer solid-in-water emulsion) was fabricated by cooling the emulsion. The particle morphology and particle size were evaluated using scanning electron microscope.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalApplied Surface Science
Volume262
DOIs
Publication statusPublished - Dec 1 2012
Externally publishedYes

Keywords

  • Coating
  • Hydroxyapatite
  • Microsphere
  • Nanoparticle
  • Pickering emulsion

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Physics and Astronomy(all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films

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