Soluble forms of the selectin family in children with Kawasaki disease: Prediction for coronary artery lesions

J. Furui, M. Ishii, H. Ikeda, H. Muta, K. Egami, Y. Sugahara, W. Himeno, Teiji Akagi, H. Kato, T. Matsuishi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: To investigate the relationship between the plasma levels of soluble forms of the selectin family and the incidence of coronary artery lesions (CALs) in patients with Kawasaki disease (KD). Methods: Thirty-three patients with KD, including group A patients (n = 22) who had no CALs and group B patients (n = 11) who had CALs, as well as age-matched febrile (n = 10) and afebrile controls (n = 11), were studied. Results: Peak plasma E-selectin levels (172.0 ± 58.6 ng ml-1) occurred during the acute phase of KD, while peak plasma P-selectin levels (260.3 ± 43.2 ng ml-1) occurred during the subacute phase of the illness (p ≤ 0.05). Plasma L-selectin levels (1757.3 ± 244.3 ng ml-1) during the convalescent phase tended to be higher than in either the acute or the subacute phase (not significant). Before intravenous immunoglobulin treatment, the plasma levels of E- (225.1 ± 46.8 ng ml-1) and P-selectin (259.4 ± 76.2 ng ml-1) of patients with CALs (n = 11) were significantly higher than those of patients (n = 22) with no CALs (E-selectin, 131.6 ± 36.9 ng ml-1; P-selectin, 184.9 ± 84.6 ng ml-1; p <0.05). When a plasma E-selectin value before immunoglobulin treatment of >184.7 ng ml-1 was used as the cut-off point, the sensitivity and specificity for the incidence of CALs were 81.8% and 90.9%, respectively. These findings demonstrate the relationship between plasma levels of selectins and disease severity of Kawasaki vasculitis. Conclusion: Higher plasma levels of E-selectin may have potential as a predictor of the incidence of coronary artery lesions in Kawasaki disease patients.

Original languageEnglish
Pages (from-to)1183-1188
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Volume91
Issue number11
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Selectins
Mucocutaneous Lymph Node Syndrome
Coronary Vessels
P-Selectin
E-Selectin
Incidence
L-Selectin
Intravenous Immunoglobulins
Vasculitis
Fever
Sensitivity and Specificity

Keywords

  • Coronary artery lesions
  • Kawasaki disease
  • Selectin family
  • Vasculitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Soluble forms of the selectin family in children with Kawasaki disease : Prediction for coronary artery lesions. / Furui, J.; Ishii, M.; Ikeda, H.; Muta, H.; Egami, K.; Sugahara, Y.; Himeno, W.; Akagi, Teiji; Kato, H.; Matsuishi, T.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 91, No. 11, 2002, p. 1183-1188.

Research output: Contribution to journalArticle

Furui, J. ; Ishii, M. ; Ikeda, H. ; Muta, H. ; Egami, K. ; Sugahara, Y. ; Himeno, W. ; Akagi, Teiji ; Kato, H. ; Matsuishi, T. / Soluble forms of the selectin family in children with Kawasaki disease : Prediction for coronary artery lesions. In: Acta Paediatrica, International Journal of Paediatrics. 2002 ; Vol. 91, No. 11. pp. 1183-1188.
@article{167aa0e99796458d85460fba097790dc,
title = "Soluble forms of the selectin family in children with Kawasaki disease: Prediction for coronary artery lesions",
abstract = "Aim: To investigate the relationship between the plasma levels of soluble forms of the selectin family and the incidence of coronary artery lesions (CALs) in patients with Kawasaki disease (KD). Methods: Thirty-three patients with KD, including group A patients (n = 22) who had no CALs and group B patients (n = 11) who had CALs, as well as age-matched febrile (n = 10) and afebrile controls (n = 11), were studied. Results: Peak plasma E-selectin levels (172.0 ± 58.6 ng ml-1) occurred during the acute phase of KD, while peak plasma P-selectin levels (260.3 ± 43.2 ng ml-1) occurred during the subacute phase of the illness (p ≤ 0.05). Plasma L-selectin levels (1757.3 ± 244.3 ng ml-1) during the convalescent phase tended to be higher than in either the acute or the subacute phase (not significant). Before intravenous immunoglobulin treatment, the plasma levels of E- (225.1 ± 46.8 ng ml-1) and P-selectin (259.4 ± 76.2 ng ml-1) of patients with CALs (n = 11) were significantly higher than those of patients (n = 22) with no CALs (E-selectin, 131.6 ± 36.9 ng ml-1; P-selectin, 184.9 ± 84.6 ng ml-1; p <0.05). When a plasma E-selectin value before immunoglobulin treatment of >184.7 ng ml-1 was used as the cut-off point, the sensitivity and specificity for the incidence of CALs were 81.8{\%} and 90.9{\%}, respectively. These findings demonstrate the relationship between plasma levels of selectins and disease severity of Kawasaki vasculitis. Conclusion: Higher plasma levels of E-selectin may have potential as a predictor of the incidence of coronary artery lesions in Kawasaki disease patients.",
keywords = "Coronary artery lesions, Kawasaki disease, Selectin family, Vasculitis",
author = "J. Furui and M. Ishii and H. Ikeda and H. Muta and K. Egami and Y. Sugahara and W. Himeno and Teiji Akagi and H. Kato and T. Matsuishi",
year = "2002",
doi = "10.1080/080352502320777414",
language = "English",
volume = "91",
pages = "1183--1188",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Soluble forms of the selectin family in children with Kawasaki disease

T2 - Prediction for coronary artery lesions

AU - Furui, J.

AU - Ishii, M.

AU - Ikeda, H.

AU - Muta, H.

AU - Egami, K.

AU - Sugahara, Y.

AU - Himeno, W.

AU - Akagi, Teiji

AU - Kato, H.

AU - Matsuishi, T.

PY - 2002

Y1 - 2002

N2 - Aim: To investigate the relationship between the plasma levels of soluble forms of the selectin family and the incidence of coronary artery lesions (CALs) in patients with Kawasaki disease (KD). Methods: Thirty-three patients with KD, including group A patients (n = 22) who had no CALs and group B patients (n = 11) who had CALs, as well as age-matched febrile (n = 10) and afebrile controls (n = 11), were studied. Results: Peak plasma E-selectin levels (172.0 ± 58.6 ng ml-1) occurred during the acute phase of KD, while peak plasma P-selectin levels (260.3 ± 43.2 ng ml-1) occurred during the subacute phase of the illness (p ≤ 0.05). Plasma L-selectin levels (1757.3 ± 244.3 ng ml-1) during the convalescent phase tended to be higher than in either the acute or the subacute phase (not significant). Before intravenous immunoglobulin treatment, the plasma levels of E- (225.1 ± 46.8 ng ml-1) and P-selectin (259.4 ± 76.2 ng ml-1) of patients with CALs (n = 11) were significantly higher than those of patients (n = 22) with no CALs (E-selectin, 131.6 ± 36.9 ng ml-1; P-selectin, 184.9 ± 84.6 ng ml-1; p <0.05). When a plasma E-selectin value before immunoglobulin treatment of >184.7 ng ml-1 was used as the cut-off point, the sensitivity and specificity for the incidence of CALs were 81.8% and 90.9%, respectively. These findings demonstrate the relationship between plasma levels of selectins and disease severity of Kawasaki vasculitis. Conclusion: Higher plasma levels of E-selectin may have potential as a predictor of the incidence of coronary artery lesions in Kawasaki disease patients.

AB - Aim: To investigate the relationship between the plasma levels of soluble forms of the selectin family and the incidence of coronary artery lesions (CALs) in patients with Kawasaki disease (KD). Methods: Thirty-three patients with KD, including group A patients (n = 22) who had no CALs and group B patients (n = 11) who had CALs, as well as age-matched febrile (n = 10) and afebrile controls (n = 11), were studied. Results: Peak plasma E-selectin levels (172.0 ± 58.6 ng ml-1) occurred during the acute phase of KD, while peak plasma P-selectin levels (260.3 ± 43.2 ng ml-1) occurred during the subacute phase of the illness (p ≤ 0.05). Plasma L-selectin levels (1757.3 ± 244.3 ng ml-1) during the convalescent phase tended to be higher than in either the acute or the subacute phase (not significant). Before intravenous immunoglobulin treatment, the plasma levels of E- (225.1 ± 46.8 ng ml-1) and P-selectin (259.4 ± 76.2 ng ml-1) of patients with CALs (n = 11) were significantly higher than those of patients (n = 22) with no CALs (E-selectin, 131.6 ± 36.9 ng ml-1; P-selectin, 184.9 ± 84.6 ng ml-1; p <0.05). When a plasma E-selectin value before immunoglobulin treatment of >184.7 ng ml-1 was used as the cut-off point, the sensitivity and specificity for the incidence of CALs were 81.8% and 90.9%, respectively. These findings demonstrate the relationship between plasma levels of selectins and disease severity of Kawasaki vasculitis. Conclusion: Higher plasma levels of E-selectin may have potential as a predictor of the incidence of coronary artery lesions in Kawasaki disease patients.

KW - Coronary artery lesions

KW - Kawasaki disease

KW - Selectin family

KW - Vasculitis

UR - http://www.scopus.com/inward/record.url?scp=18744401875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18744401875&partnerID=8YFLogxK

U2 - 10.1080/080352502320777414

DO - 10.1080/080352502320777414

M3 - Article

C2 - 12463316

AN - SCOPUS:18744401875

VL - 91

SP - 1183

EP - 1188

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 11

ER -