Solid pseudopapillary neoplasm: pathological diagnosis and distinction from other solid cellular tumours of the pancreas

Kenji Notohara, Yoji Wani, Masayoshi Fujisawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumour with low malignant potential. It is clinically distinct from other pancreatic tumours, and the proper diagnosis is crucial for patient management. However, the histological features of SPN are variable and its diagnosis is not always straightforward. Finger-like extension of the tumour into the surrounding pancreatic parenchyma, a perpendicular cell arrangement around blood vessels and indented vesicular nuclei are characteristic histological features of SPN. The lobulated solid cell pattern seen in SPN is easily mistaken for pancreatic endocrine tumour. Immunohistochemically, SPN is consistently positive for vimentin and CD56, negative or focally positive for cytokeratin and synaptophysin, and always negative for chromogranin. Diffuse nuclear expression of β-catenin is useful for the diagnosis. The distinction of SPN from other solid cellular neoplasms can be made by careful histological observation as well as using a panel of immunohistochemical markers.

Original languageEnglish
Pages (from-to)266-274
Number of pages9
JournalDiagnostic Histopathology
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 1 2008
Externally publishedYes

Keywords

  • immunohistochemistry
  • pancreatic endocrine tumour
  • pathology
  • solid pseudopapillary neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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