Abstract
An amorphous solid dispersion technique, in which hydrophobic drug molecules are dispersed in an amorphous matrix comprised solely of a sugar, was applied to curcumin that has excellent physiological functions. The sole-amorphous-sugar-based solid dispersion (SAS-SD) of curcumin was prepared by vacuum foam drying from methanol, using various disaccharides as the drug carrier-forming component. Aqueous dissolution of curcumin from the SAS-SD showed “spring-and-parachute” shape profile and was markedly increased when a sugar (α-maltose or trehalose) was added in a composition range ≥100 g-sugar/g-curcumin. Further dissolution was achieved by heating the SAS-SD at close to and above the melting points of curcumin.
Original language | English |
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Pages (from-to) | 2065-2074 |
Number of pages | 10 |
Journal | Drying Technology |
Volume | 39 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- Solid dispersion
- amorphous sugar
- curcumin
- spring and parachute
ASJC Scopus subject areas
- Chemical Engineering(all)
- Physical and Theoretical Chemistry