Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

Qiaozhi Wei, Fumio Nakahara, Noboru Asada, Dachuan Zhang, Xin Gao, Chunliang Xu, Alan Alfieri, N. Patrik Brodin, Samuel E. Zimmerman, Jessica C. Mar, Chandan Guha, Wenjun Guo, Paul S. Frenette

Research output: Contribution to journalArticle

Abstract

Wei et al. found that Snai2 is preferentially expressed and required in bone marrow mesenchymal stem and progenitor cells (MSPCs) for their maintenance and regeneration. The authors show that Snai2 promotes self-renewal by suppressing Spp1 expression in MSPCs.

Original languageEnglish
Pages (from-to)503-513.e5
JournalDevelopmental Cell
Volume53
Issue number5
DOIs
Publication statusPublished - Jun 8 2020
Externally publishedYes

Keywords

  • Snai2/Slug
  • bone marrow
  • hematopoietic stem cell niche
  • mesenchymal stem and progenitor cells
  • osteopontin/Spp1
  • self-renewal
  • stromal cells
  • transcriptional regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Wei, Q., Nakahara, F., Asada, N., Zhang, D., Gao, X., Xu, C., Alfieri, A., Brodin, N. P., Zimmerman, S. E., Mar, J. C., Guha, C., Guo, W., & Frenette, P. S. (2020). Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression. Developmental Cell, 53(5), 503-513.e5. https://doi.org/10.1016/j.devcel.2020.04.012