Abstract
Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 636-639 |
| Number of pages | 4 |
| Journal | Diagnostic Cytopathology |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2013 |
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Keywords
- large cell neuroendocrine carcinoma
- smear cytology
- uterine cervix
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
Cite this
Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix. / Kuroda, Naoto; Wada, Yukari; Inoue, Kaori; Ohara, Masahiko; Mizuno, Keiko; Toi, Makoto; Tanaka, Azusa; Wani, Yoji; Yanai, Hiroyuki.
In: Diagnostic Cytopathology, Vol. 41, No. 7, 07.2013, p. 636-639.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix
AU - Kuroda, Naoto
AU - Wada, Yukari
AU - Inoue, Kaori
AU - Ohara, Masahiko
AU - Mizuno, Keiko
AU - Toi, Makoto
AU - Tanaka, Azusa
AU - Wani, Yoji
AU - Yanai, Hiroyuki
PY - 2013/7
Y1 - 2013/7
N2 - Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor.
AB - Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor.
KW - large cell neuroendocrine carcinoma
KW - smear cytology
KW - uterine cervix
UR - http://www.scopus.com/inward/record.url?scp=84879419378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879419378&partnerID=8YFLogxK
U2 - 10.1002/dc.21834
DO - 10.1002/dc.21834
M3 - Article
C2 - 21987295
AN - SCOPUS:84879419378
VL - 41
SP - 636
EP - 639
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
SN - 8755-1039
IS - 7
ER -