Abstract
The aim of this study was the evaluation of preliminary suitability of the piglet small intestinal submucosa (SIS) sandwich Zilver endograft for experimental transjugular intrahepatic portosystemic shunt (TIPS) creation. TIPS was created in six swine. The five surviving animals underwent the follow-up portogram and were sacrificed at four weeks after TIPS creation. Gross and histologic examination was performed in all animals. TIPS creation was successful in all animals. One animal died four days after TIPS creation. In the five surviving animals, one shunt was occluded and four shunts were stenosed on the follow-up portogram. The mean percentage narrowing of the most advanced stenoses was 72% (range, 60%-100%). The most advanced stenosis was located in the parenchymal tract in three shunts and in the hepatic vein portion in one shunt. Gross and histologic examination showed abundant neointimal formation composed mainly of fibroblasts leading to the significant shunt stenoses. The piglet SIS sandwich Zilver stent-graft was found to offer only limited TIPS patency and should not be used for the definitive long-term TIPS study.
| Original language | English |
|---|---|
| Pages (from-to) | 32-38 |
| Number of pages | 7 |
| Journal | Minimally Invasive Therapy and Allied Technologies |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 |
| Externally published | Yes |
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Keywords
- Endovascular stent grafts; shunts
- Interventional procedure
- Portosystemic; stents and prostheses; liver
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Surgery
Cite this
Small intestinal submucosa sandwich Zilver stent-grafts for TIPS : Experimental pilot study in swine. / Hiraki, T.; Pavcnik, D.; Uchida, B. T.; Timmermans, H. A.; Wu, R. H.; Niyyati, M.; Keller, F. S.; Rösch, J.
In: Minimally Invasive Therapy and Allied Technologies, Vol. 14, No. 1, 2005, p. 32-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Small intestinal submucosa sandwich Zilver stent-grafts for TIPS
T2 - Experimental pilot study in swine
AU - Hiraki, T.
AU - Pavcnik, D.
AU - Uchida, B. T.
AU - Timmermans, H. A.
AU - Wu, R. H.
AU - Niyyati, M.
AU - Keller, F. S.
AU - Rösch, J.
PY - 2005
Y1 - 2005
N2 - The aim of this study was the evaluation of preliminary suitability of the piglet small intestinal submucosa (SIS) sandwich Zilver endograft for experimental transjugular intrahepatic portosystemic shunt (TIPS) creation. TIPS was created in six swine. The five surviving animals underwent the follow-up portogram and were sacrificed at four weeks after TIPS creation. Gross and histologic examination was performed in all animals. TIPS creation was successful in all animals. One animal died four days after TIPS creation. In the five surviving animals, one shunt was occluded and four shunts were stenosed on the follow-up portogram. The mean percentage narrowing of the most advanced stenoses was 72% (range, 60%-100%). The most advanced stenosis was located in the parenchymal tract in three shunts and in the hepatic vein portion in one shunt. Gross and histologic examination showed abundant neointimal formation composed mainly of fibroblasts leading to the significant shunt stenoses. The piglet SIS sandwich Zilver stent-graft was found to offer only limited TIPS patency and should not be used for the definitive long-term TIPS study.
AB - The aim of this study was the evaluation of preliminary suitability of the piglet small intestinal submucosa (SIS) sandwich Zilver endograft for experimental transjugular intrahepatic portosystemic shunt (TIPS) creation. TIPS was created in six swine. The five surviving animals underwent the follow-up portogram and were sacrificed at four weeks after TIPS creation. Gross and histologic examination was performed in all animals. TIPS creation was successful in all animals. One animal died four days after TIPS creation. In the five surviving animals, one shunt was occluded and four shunts were stenosed on the follow-up portogram. The mean percentage narrowing of the most advanced stenoses was 72% (range, 60%-100%). The most advanced stenosis was located in the parenchymal tract in three shunts and in the hepatic vein portion in one shunt. Gross and histologic examination showed abundant neointimal formation composed mainly of fibroblasts leading to the significant shunt stenoses. The piglet SIS sandwich Zilver stent-graft was found to offer only limited TIPS patency and should not be used for the definitive long-term TIPS study.
KW - Endovascular stent grafts; shunts
KW - Interventional procedure
KW - Portosystemic; stents and prostheses; liver
UR - http://www.scopus.com/inward/record.url?scp=14944379579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14944379579&partnerID=8YFLogxK
U2 - 10.1080/13645700510010818
DO - 10.1080/13645700510010818
M3 - Article
VL - 14
SP - 32
EP - 38
JO - Minimally Invasive Therapy and Allied Technologies
JF - Minimally Invasive Therapy and Allied Technologies
SN - 1364-5706
IS - 1
ER -