Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index

Yoshizo Kimura, Kensaku Sato, Yutaka Imamura, Fumiko Arakawa, Junichi Kiyasu, Masanori Takeuchi, Hiroaki Miyoshi, Maki Yoshida, Daisuke Niino, Yasuo Sugita, Toshiaki Morito, Tadashi Yoshino, Shigeo Nakamura, Koichi Ohshima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Mantle cell lymphoma (MCL) is recognized as a well-defined B cell neoplasm characterized by overexpression of cyclin D1 (CCND1), with "classical" and "aggressive" variant subtypes. A small-cell variant of MCL (small-MCL), resembling small lymphocytic lymphoma/chronic lymphocytic lymphoma (CLL/SLL), has been added to the World Health Organization classification. However, to the best of our knowledge, there have been no studies focusing on this neoplasm. In the present study, we analyzed 15 cases of CCND1-positive small-MCL, including immunohistochemical analysis of Ki-67 and CCND1 expression, and compared our findings with those of 151 cases of classical MCL. Morphologically, most small-MCL showed a diffuse growth pattern (76.9%), whereas others featured a very thin mantle zone pattern resembling a reactive follicle (23.1%). Bone marrow involvement and splenomegaly occurred significantly more frequently in small-MCL than in classical MCL (P

Original languageEnglish
Pages (from-to)1734-1741
Number of pages8
JournalCancer Science
Volume102
Issue number9
DOIs
Publication statusPublished - Sep 2011

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kimura, Y., Sato, K., Imamura, Y., Arakawa, F., Kiyasu, J., Takeuchi, M., Miyoshi, H., Yoshida, M., Niino, D., Sugita, Y., Morito, T., Yoshino, T., Nakamura, S., & Ohshima, K. (2011). Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index. Cancer Science, 102(9), 1734-1741. https://doi.org/10.1111/j.1349-7006.2011.01988.x