Abstract
The prevalence of stage 3 to 5 chronic kidney disease (CKD) in Japan (18.7%) is considerably higher than that in the United States (4.5%). This study investigated in the Japanese general population whether this higher prevalence of CKD might reflect to a progressive decline of renal function, and in turn to the increased risk of end-stage renal disease. A decline in renal function over 10 years was examined in 120,727 individuals aged 40 years or older who participated in the annual health examination program of the two periods over 10 years, 1988-1993 and 1998-2003. Renal function was assessed with estimated glomerular filtration rate (GFR) using the abbreviated Modification of Diet in Renal Disease (MDRD) Study equation modified by a Japanese coefficient. The rate of GFR decline in the participants was 0.36 mL/min/1.73 m2/ year on average. In the male population aged 50-79, the mean rate of GFR decline was significantly higher in the presence of hypertension than in its absence. The rate of GFR decline was more than two times higher in participants with proteinuria than in those without proteinuria in both sexes. The rate was significantly higher in participants with an initial GFR <50 mL/min/1.73 m2 among the groups younger than age 70 and in participants with an initial GFR <40 mL/min/1.73 m2 in the group with age 70-79. Based on the slow rate of GFR decline, we concluded that the decline in renal function progresses slowly in the Japanese general population. Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR.
| Original language | English |
|---|---|
| Pages (from-to) | 433-441 |
| Number of pages | 9 |
| Journal | Hypertension Research |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2008 |
Fingerprint
Keywords
- Equation
- Glomerular filtration rate
- Japanese
- Modification of Diet in Renal Disease
ASJC Scopus subject areas
- Internal Medicine
Cite this
Slower decline of glomerular filtration rate in the Japanese general population : A longitudinal 10-year follow-up study. / Imai, Enyu; Horio, Masaru; Yamagata, Kunihiro; Iseki, Kunitoshi; Hara, Shigeko; Ura, Nobuyuki; Kiyohara, Yutaka; Makino, Hirofumi; Hishida, Akira; Matsuo, Seiichi.
In: Hypertension Research, Vol. 31, No. 3, 01.03.2008, p. 433-441.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Slower decline of glomerular filtration rate in the Japanese general population
T2 - A longitudinal 10-year follow-up study
AU - Imai, Enyu
AU - Horio, Masaru
AU - Yamagata, Kunihiro
AU - Iseki, Kunitoshi
AU - Hara, Shigeko
AU - Ura, Nobuyuki
AU - Kiyohara, Yutaka
AU - Makino, Hirofumi
AU - Hishida, Akira
AU - Matsuo, Seiichi
PY - 2008/3/1
Y1 - 2008/3/1
N2 - The prevalence of stage 3 to 5 chronic kidney disease (CKD) in Japan (18.7%) is considerably higher than that in the United States (4.5%). This study investigated in the Japanese general population whether this higher prevalence of CKD might reflect to a progressive decline of renal function, and in turn to the increased risk of end-stage renal disease. A decline in renal function over 10 years was examined in 120,727 individuals aged 40 years or older who participated in the annual health examination program of the two periods over 10 years, 1988-1993 and 1998-2003. Renal function was assessed with estimated glomerular filtration rate (GFR) using the abbreviated Modification of Diet in Renal Disease (MDRD) Study equation modified by a Japanese coefficient. The rate of GFR decline in the participants was 0.36 mL/min/1.73 m2/ year on average. In the male population aged 50-79, the mean rate of GFR decline was significantly higher in the presence of hypertension than in its absence. The rate of GFR decline was more than two times higher in participants with proteinuria than in those without proteinuria in both sexes. The rate was significantly higher in participants with an initial GFR <50 mL/min/1.73 m2 among the groups younger than age 70 and in participants with an initial GFR <40 mL/min/1.73 m2 in the group with age 70-79. Based on the slow rate of GFR decline, we concluded that the decline in renal function progresses slowly in the Japanese general population. Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR.
AB - The prevalence of stage 3 to 5 chronic kidney disease (CKD) in Japan (18.7%) is considerably higher than that in the United States (4.5%). This study investigated in the Japanese general population whether this higher prevalence of CKD might reflect to a progressive decline of renal function, and in turn to the increased risk of end-stage renal disease. A decline in renal function over 10 years was examined in 120,727 individuals aged 40 years or older who participated in the annual health examination program of the two periods over 10 years, 1988-1993 and 1998-2003. Renal function was assessed with estimated glomerular filtration rate (GFR) using the abbreviated Modification of Diet in Renal Disease (MDRD) Study equation modified by a Japanese coefficient. The rate of GFR decline in the participants was 0.36 mL/min/1.73 m2/ year on average. In the male population aged 50-79, the mean rate of GFR decline was significantly higher in the presence of hypertension than in its absence. The rate of GFR decline was more than two times higher in participants with proteinuria than in those without proteinuria in both sexes. The rate was significantly higher in participants with an initial GFR <50 mL/min/1.73 m2 among the groups younger than age 70 and in participants with an initial GFR <40 mL/min/1.73 m2 in the group with age 70-79. Based on the slow rate of GFR decline, we concluded that the decline in renal function progresses slowly in the Japanese general population. Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR.
KW - Equation
KW - Glomerular filtration rate
KW - Japanese
KW - Modification of Diet in Renal Disease
UR - http://www.scopus.com/inward/record.url?scp=42649121378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42649121378&partnerID=8YFLogxK
U2 - 10.1291/hypres.31.433
DO - 10.1291/hypres.31.433
M3 - Article
VL - 31
SP - 433
EP - 441
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 3
ER -