Abstract
Background Sleep disordered breathing (SDB) is associated with decreased psychomotor vigilance (hereafter “vigilance”) in clinical settings, but this association has yet to be confirmed in the general population. The aim of this study is to determine the associations between SDB and vigilance in a large sample of community-based participants. Methods The study sample consisted of 1508 community-dwelling Japanese persons (age: 30–79 years, women: 62.7%, mean body mass index [BMI]: 23.1 kg/m2). Vigilance was measured by the psychomotor vigilance task (PVT), and SDB was measured by overnight pulse oximetry. We investigated odds ratios for “high mean reaction time (RT)” and “high number of lapses,” which we defined as the 75th percentile of each value, across categories of oximetry values (three percent oxygen desaturation index [ODI], 4% ODI, average oxygen saturation, minimum oxygen saturation). Results Multivariable-adjusted odds ratios of high mean RT and high number of lapses in severe SDB (3% ODI ≥ 30.0 events/h) were 3.0 (95% confidence interval: 1.0–8.9; P for trend = 0.03) and 3.3 (95% confidence interval: 1.2–9.2, P for trend = 0.03), respectively, compared to participants without SDB. Similar associations were observed between PVT metrics and four percent ODI. No significant associations between average oxygen saturation and PVT metrics were observed. Minimum oxygen saturation was significantly associated with the trend of high number of lapses (P for trend = 0.007), but not with high mean RT. Conclusions The present study provides evidence that the intermittent hypoxia in SDB is significantly associated with the deterioration of PVT outcome metrics.
| Original language | English |
|---|---|
| Pages (from-to) | 7-12 |
| Number of pages | 6 |
| Journal | Sleep Medicine |
| Volume | 29 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
Fingerprint
Keywords
- Cross-sectional study
- Epidemiology
- Psychomotor vigilance task
- Sleep apnea
- Sleep disordered breathing
- Vigilance
ASJC Scopus subject areas
- Medicine(all)
Cite this
Sleep-related intermittent hypoxia is associated with decreased psychomotor vigilance in Japanese community residents. / Tanno, Sakurako; Tanigawa, Takeshi; Maruyama, Koutatsu; Eguchi, Eri; Abe, Takashi; Saito, Isao.
In: Sleep Medicine, Vol. 29, 01.01.2017, p. 7-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sleep-related intermittent hypoxia is associated with decreased psychomotor vigilance in Japanese community residents
AU - Tanno, Sakurako
AU - Tanigawa, Takeshi
AU - Maruyama, Koutatsu
AU - Eguchi, Eri
AU - Abe, Takashi
AU - Saito, Isao
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background Sleep disordered breathing (SDB) is associated with decreased psychomotor vigilance (hereafter “vigilance”) in clinical settings, but this association has yet to be confirmed in the general population. The aim of this study is to determine the associations between SDB and vigilance in a large sample of community-based participants. Methods The study sample consisted of 1508 community-dwelling Japanese persons (age: 30–79 years, women: 62.7%, mean body mass index [BMI]: 23.1 kg/m2). Vigilance was measured by the psychomotor vigilance task (PVT), and SDB was measured by overnight pulse oximetry. We investigated odds ratios for “high mean reaction time (RT)” and “high number of lapses,” which we defined as the 75th percentile of each value, across categories of oximetry values (three percent oxygen desaturation index [ODI], 4% ODI, average oxygen saturation, minimum oxygen saturation). Results Multivariable-adjusted odds ratios of high mean RT and high number of lapses in severe SDB (3% ODI ≥ 30.0 events/h) were 3.0 (95% confidence interval: 1.0–8.9; P for trend = 0.03) and 3.3 (95% confidence interval: 1.2–9.2, P for trend = 0.03), respectively, compared to participants without SDB. Similar associations were observed between PVT metrics and four percent ODI. No significant associations between average oxygen saturation and PVT metrics were observed. Minimum oxygen saturation was significantly associated with the trend of high number of lapses (P for trend = 0.007), but not with high mean RT. Conclusions The present study provides evidence that the intermittent hypoxia in SDB is significantly associated with the deterioration of PVT outcome metrics.
AB - Background Sleep disordered breathing (SDB) is associated with decreased psychomotor vigilance (hereafter “vigilance”) in clinical settings, but this association has yet to be confirmed in the general population. The aim of this study is to determine the associations between SDB and vigilance in a large sample of community-based participants. Methods The study sample consisted of 1508 community-dwelling Japanese persons (age: 30–79 years, women: 62.7%, mean body mass index [BMI]: 23.1 kg/m2). Vigilance was measured by the psychomotor vigilance task (PVT), and SDB was measured by overnight pulse oximetry. We investigated odds ratios for “high mean reaction time (RT)” and “high number of lapses,” which we defined as the 75th percentile of each value, across categories of oximetry values (three percent oxygen desaturation index [ODI], 4% ODI, average oxygen saturation, minimum oxygen saturation). Results Multivariable-adjusted odds ratios of high mean RT and high number of lapses in severe SDB (3% ODI ≥ 30.0 events/h) were 3.0 (95% confidence interval: 1.0–8.9; P for trend = 0.03) and 3.3 (95% confidence interval: 1.2–9.2, P for trend = 0.03), respectively, compared to participants without SDB. Similar associations were observed between PVT metrics and four percent ODI. No significant associations between average oxygen saturation and PVT metrics were observed. Minimum oxygen saturation was significantly associated with the trend of high number of lapses (P for trend = 0.007), but not with high mean RT. Conclusions The present study provides evidence that the intermittent hypoxia in SDB is significantly associated with the deterioration of PVT outcome metrics.
KW - Cross-sectional study
KW - Epidemiology
KW - Psychomotor vigilance task
KW - Sleep apnea
KW - Sleep disordered breathing
KW - Vigilance
UR - http://www.scopus.com/inward/record.url?scp=85004065480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85004065480&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2016.08.024
DO - 10.1016/j.sleep.2016.08.024
M3 - Article
C2 - 28153218
AN - SCOPUS:85004065480
VL - 29
SP - 7
EP - 12
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
ER -