Skin sympathetic outflow in Buerger's disease

Satoshi Iwase, Tetsuya Okamoto, Tadaaki Mano, Atsunori Kamiya, Yuki Niimi, Fu Qi, Naomichi Nishikimi, Tsunehisa Sakurai, Yuji Nimura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To clarify if sympathetic outflow is altered in Buerger's disease (thromboangitis obliterans, TAO), we measured skin sympathetic nerve activity (SSNA) in TAO patients, and observed the sweating and vasoconstrictive responses during resting and with activating maneuvers. Multiunit postganglionic sympathetic activity was recorded in a skin fascicle of the tibial nerve innervating the skin of the sole (glabrous skin) and peroneal nerve innervating the skin of the dorsum pedis (hairy skin) from five TAO patients and five healthy subjects simultaneously with skin blood flow and sweat expulsion. TAO patients showed significantly less vasoconstrictor SSNA than healthy subjects (17.0±1.9 vs. 31.5±5.8 bursts/min, P<0.001). Moreover, we found no relationship between vasoconstrictor SSNA and skin blood flow in some patients, while they were well correlated in healthy subjects. There was no evidence for increased sympathetic activity in TAO patients, and no hypersensitive relationship was found between SSNA and skin blood flow. These observations suggested that these TAO patients exhibiting no relationship between skin blood flow reduction and vasoconstrictor activity might not respond to sympathectomy, which is generally expected to result in an increase in skin blood flow. The absence of increased sympathetic nerve activity provides further indirect evidence of a local vascular abnormality in TAO.

Original languageEnglish
Pages (from-to)286-292
Number of pages7
JournalAutonomic Neuroscience: Basic and Clinical
Volume87
Issue number2-3
DOIs
Publication statusPublished - Mar 23 2001
Externally publishedYes

Fingerprint

Thromboangiitis Obliterans
Skin
Vasoconstrictor Agents
Healthy Volunteers
Tibial Nerve
Peroneal Nerve
Sympathectomy
Sweating
Sweat

Keywords

  • Buerger's disease
  • Microneurography
  • Skin blood flow
  • Skin sympathetic nerve activity
  • Sweat expulsion

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Iwase, S., Okamoto, T., Mano, T., Kamiya, A., Niimi, Y., Qi, F., ... Nimura, Y. (2001). Skin sympathetic outflow in Buerger's disease. Autonomic Neuroscience: Basic and Clinical, 87(2-3), 286-292. https://doi.org/10.1016/S1566-0702(00)00272-1

Skin sympathetic outflow in Buerger's disease. / Iwase, Satoshi; Okamoto, Tetsuya; Mano, Tadaaki; Kamiya, Atsunori; Niimi, Yuki; Qi, Fu; Nishikimi, Naomichi; Sakurai, Tsunehisa; Nimura, Yuji.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 87, No. 2-3, 23.03.2001, p. 286-292.

Research output: Contribution to journalArticle

Iwase, S, Okamoto, T, Mano, T, Kamiya, A, Niimi, Y, Qi, F, Nishikimi, N, Sakurai, T & Nimura, Y 2001, 'Skin sympathetic outflow in Buerger's disease', Autonomic Neuroscience: Basic and Clinical, vol. 87, no. 2-3, pp. 286-292. https://doi.org/10.1016/S1566-0702(00)00272-1
Iwase, Satoshi ; Okamoto, Tetsuya ; Mano, Tadaaki ; Kamiya, Atsunori ; Niimi, Yuki ; Qi, Fu ; Nishikimi, Naomichi ; Sakurai, Tsunehisa ; Nimura, Yuji. / Skin sympathetic outflow in Buerger's disease. In: Autonomic Neuroscience: Basic and Clinical. 2001 ; Vol. 87, No. 2-3. pp. 286-292.
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