Site dependence of bone formation induced by rhBMP-2: comparing rate parietal bone and heterotopic back region

H. Nagatsuka, N. Nagai, T. Sakae, R. Z. Legeros

Research output: Contribution to journalConference article

Abstract

The purpose of this study was to compare the rate of bone formation and progression induced by Rh-BMP-2/atelocollagen complex between the periosteal and dermis regions in rats. In both cases, mature bone formation was preceded by mesenchymal cell proliferation and immature bone formation. In the periosteal region, bone formation was rapid: tissues were almost fully occupied with bone after 6 weeks of implantation, whereas in the dermis region bone tissue was only 80% occupied even after 24 weeks. Vascularization occurred at the cavities of the implant and appeared to be necessary in the formation of immature bone.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalKey Engineering Materials
Volume192-195
Publication statusPublished - 2001
Event13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy
Duration: Nov 22 2000Nov 26 2000

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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