Site dependence of bone formation induced by rhBMP-2: comparing rate parietal bone and heterotopic back region

Hitoshi Nagatsuka, N. Nagai, T. Sakae, R. Z. Legeros

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to compare the rate of bone formation and progression induced by Rh-BMP-2/atelocollagen complex between the periosteal and dermis regions in rats. In both cases, mature bone formation was preceded by mesenchymal cell proliferation and immature bone formation. In the periosteal region, bone formation was rapid: tissues were almost fully occupied with bone after 6 weeks of implantation, whereas in the dermis region bone tissue was only 80% occupied even after 24 weeks. Vascularization occurred at the cavities of the implant and appeared to be necessary in the formation of immature bone.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalKey Engineering Materials
Volume192-195
Publication statusPublished - 2001

Fingerprint

Bone
Tissue
Cell proliferation
Rats

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites

Cite this

Site dependence of bone formation induced by rhBMP-2 : comparing rate parietal bone and heterotopic back region. / Nagatsuka, Hitoshi; Nagai, N.; Sakae, T.; Legeros, R. Z.

In: Key Engineering Materials, Vol. 192-195, 2001, p. 511-514.

Research output: Contribution to journalArticle

@article{a60cae2132824232802d68b9be662d7f,
title = "Site dependence of bone formation induced by rhBMP-2: comparing rate parietal bone and heterotopic back region",
abstract = "The purpose of this study was to compare the rate of bone formation and progression induced by Rh-BMP-2/atelocollagen complex between the periosteal and dermis regions in rats. In both cases, mature bone formation was preceded by mesenchymal cell proliferation and immature bone formation. In the periosteal region, bone formation was rapid: tissues were almost fully occupied with bone after 6 weeks of implantation, whereas in the dermis region bone tissue was only 80{\%} occupied even after 24 weeks. Vascularization occurred at the cavities of the implant and appeared to be necessary in the formation of immature bone.",
author = "Hitoshi Nagatsuka and N. Nagai and T. Sakae and Legeros, {R. Z.}",
year = "2001",
language = "English",
volume = "192-195",
pages = "511--514",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Site dependence of bone formation induced by rhBMP-2

T2 - comparing rate parietal bone and heterotopic back region

AU - Nagatsuka, Hitoshi

AU - Nagai, N.

AU - Sakae, T.

AU - Legeros, R. Z.

PY - 2001

Y1 - 2001

N2 - The purpose of this study was to compare the rate of bone formation and progression induced by Rh-BMP-2/atelocollagen complex between the periosteal and dermis regions in rats. In both cases, mature bone formation was preceded by mesenchymal cell proliferation and immature bone formation. In the periosteal region, bone formation was rapid: tissues were almost fully occupied with bone after 6 weeks of implantation, whereas in the dermis region bone tissue was only 80% occupied even after 24 weeks. Vascularization occurred at the cavities of the implant and appeared to be necessary in the formation of immature bone.

AB - The purpose of this study was to compare the rate of bone formation and progression induced by Rh-BMP-2/atelocollagen complex between the periosteal and dermis regions in rats. In both cases, mature bone formation was preceded by mesenchymal cell proliferation and immature bone formation. In the periosteal region, bone formation was rapid: tissues were almost fully occupied with bone after 6 weeks of implantation, whereas in the dermis region bone tissue was only 80% occupied even after 24 weeks. Vascularization occurred at the cavities of the implant and appeared to be necessary in the formation of immature bone.

UR - http://www.scopus.com/inward/record.url?scp=0035155309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035155309&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0035155309

VL - 192-195

SP - 511

EP - 514

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -