Sirolimus Amelioration of Clinical Symptoms of Recurrent Lymphangioleiomyomatosis After Living-donor Lobar Lung Transplantation

Ryujiro Sugimoto, Atsunori Nakao, Masaomi Yamane, Shinichi Toyooka, Megumi Okazaki, Motoi Aoe, Kuniaki Seyama, Hiroshi Date, Takahiro Oto, Yoshifumi Sano

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

In this study we report the case of a 28-year-old female patient with recurrent lymphangioleiomyomatosis (LAM) in the allografts after bilateral living-donor lobar lung transplantation. Although her post-operative course under immunosuppression with tacrolimus and prednisolone had been uneventful without rejection episodes, she had developed shortness of breath and a progressive chylous effusion with diffuse cystic changes in both lungs 5 years after transplantation. In spite of a diagnosis of having a recurrence of LAM based on radiologic findings and deteriorating pulmonary function, her clinical symptoms, which included dyspnea and chylothorax, were significantly improved after treatment with sirolimus. Although a beneficial effect of sirolimus in the treatment of LAM has not been definitively determined, this report may provide useful information for management of recurrent LAM after lung transplantation.

Original languageEnglish
Pages (from-to)921-924
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 2008

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Fingerprint Dive into the research topics of 'Sirolimus Amelioration of Clinical Symptoms of Recurrent Lymphangioleiomyomatosis After Living-donor Lobar Lung Transplantation'. Together they form a unique fingerprint.

Cite this