Sirolimus Ameliorated Post Lung Transplant Chylothorax in Lymphangioleiomyomatosis

Toshiaki Ohara, Takahiro Oto, Kentaro Miyoshi, Hiroyuki Tao, Masaomi Yamane, Shinichi Toyooka, Megumi Okazaki, Hiroshi Date, Yoshifumi Sano

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleurodesis by intrathoracic injection of OK-432, minomycin, and somatostatine analog failed to control chylous effusions. However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions.

Original languageEnglish
JournalAnnals of Thoracic Surgery
Volume86
Issue number6
DOIs
Publication statusPublished - Dec 2008

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Lymphangioleiomyomatosis
Chylothorax
Ascitic Fluid
Pleural Effusion
Sirolimus
Lung Transplantation
Transplants
Lung
Picibanil
Pleurodesis
Minocycline
Living Donors
Drainage
Injections
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Sirolimus Ameliorated Post Lung Transplant Chylothorax in Lymphangioleiomyomatosis. / Ohara, Toshiaki; Oto, Takahiro; Miyoshi, Kentaro; Tao, Hiroyuki; Yamane, Masaomi; Toyooka, Shinichi; Okazaki, Megumi; Date, Hiroshi; Sano, Yoshifumi.

In: Annals of Thoracic Surgery, Vol. 86, No. 6, 12.2008.

Research output: Contribution to journalArticle

Ohara, Toshiaki ; Oto, Takahiro ; Miyoshi, Kentaro ; Tao, Hiroyuki ; Yamane, Masaomi ; Toyooka, Shinichi ; Okazaki, Megumi ; Date, Hiroshi ; Sano, Yoshifumi. / Sirolimus Ameliorated Post Lung Transplant Chylothorax in Lymphangioleiomyomatosis. In: Annals of Thoracic Surgery. 2008 ; Vol. 86, No. 6.
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