Abstract
Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.
| Original language | English |
|---|---|
| Pages (from-to) | 832-836 |
| Number of pages | 5 |
| Journal | Neurological Research |
| Volume | 22 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jan 1 2000 |
Keywords
- Dopamine regeneration
- GDNF
- Parkinsons disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology