Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system

M. Aoi, Isao Date, S. Tomita, T. Ohmoto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.

Original languageEnglish
Pages (from-to)832-836
Number of pages5
JournalNeurological Research
Volume22
Issue number8
Publication statusPublished - 2000

Fingerprint

Glial Cell Line-Derived Neurotrophic Factor
Injections
Oxidopamine
Nerve Growth Factors
Transforming Growth Factors
Sprague Dawley Rats
Parkinson Disease

Keywords

  • Dopamine regeneration
  • GDNF
  • Parkinsons disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system. / Aoi, M.; Date, Isao; Tomita, S.; Ohmoto, T.

In: Neurological Research, Vol. 22, No. 8, 2000, p. 832-836.

Research output: Contribution to journalArticle

@article{7b32db85f6b3409a9c9171e6433d553b,
title = "Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system",
abstract = "Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.",
keywords = "Dopamine regeneration, GDNF, Parkinsons disease",
author = "M. Aoi and Isao Date and S. Tomita and T. Ohmoto",
year = "2000",
language = "English",
volume = "22",
pages = "832--836",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Maney Publishing",
number = "8",

}

TY - JOUR

T1 - Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system

AU - Aoi, M.

AU - Date, Isao

AU - Tomita, S.

AU - Ohmoto, T.

PY - 2000

Y1 - 2000

N2 - Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.

AB - Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.

KW - Dopamine regeneration

KW - GDNF

KW - Parkinsons disease

UR - http://www.scopus.com/inward/record.url?scp=0034526219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034526219&partnerID=8YFLogxK

M3 - Article

C2 - 11149247

AN - SCOPUS:0034526219

VL - 22

SP - 832

EP - 836

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 8

ER -