Abstract
Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.
| Original language | English |
|---|---|
| Pages (from-to) | 832-836 |
| Number of pages | 5 |
| Journal | Neurological Research |
| Volume | 22 |
| Issue number | 8 |
| Publication status | Published - 2000 |
Fingerprint
Keywords
- Dopamine regeneration
- GDNF
- Parkinsons disease
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system. / Aoi, M.; Date, Isao; Tomita, S.; Ohmoto, T.
In: Neurological Research, Vol. 22, No. 8, 2000, p. 832-836.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system
AU - Aoi, M.
AU - Date, Isao
AU - Tomita, S.
AU - Ohmoto, T.
PY - 2000
Y1 - 2000
N2 - Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.
AB - Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.
KW - Dopamine regeneration
KW - GDNF
KW - Parkinsons disease
UR - http://www.scopus.com/inward/record.url?scp=0034526219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034526219&partnerID=8YFLogxK
M3 - Article
C2 - 11149247
AN - SCOPUS:0034526219
VL - 22
SP - 832
EP - 836
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 8
ER -