Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system

M. Aoi, I. Date, S. Tomita, T. Ohmoto

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF at a dose of 100 μg was injected stereotactically into the striatum of Sprague-Dawley rats that had been treated with intrastriatal 6-hydroxydopamine (6-OHDA) injection four weeks earlier. Immunocytochemical and behavioral analyses showed significant recovery of the nigrostriatal dopaminergic system after a single GDNF injection or continuous GDNF injection. Immunocytochemical and behavioral study showed that there was no significant difference between the results obtained from the two different injection methods. This result demonstrates the potential usefulness of GDNF for the treatment of Parkinson's disease.

Original languageEnglish
Pages (from-to)832-836
Number of pages5
JournalNeurological Research
Volume22
Issue number8
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Dopamine regeneration
  • GDNF
  • Parkinsons disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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