Abstract
Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare auto-somal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of Pf7?A^LeulO74Phe (rsl801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN LeulO74Phe was genotyped by using a Snapshot assay. The results showed that WRN LeulO74Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR = 0.58, 95%CI: 0.35-0.97, p - 0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <72 yr (OR = 0.27, 95%CI: 0.120.61, p = 0.002) and in patients with localized diseases (OR = 0.36, 95%CI: 0.190.70, p = 0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant LeulO74Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 315-323 |
| Number of pages | 9 |
| Journal | Acta Medica Okayama |
| Volume | 65 |
| Issue number | 5 |
| Publication status | Published - 2011 |
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Keywords
- Polymorphism
- Prostatic neoplasms
- Single nucleotide
- Susceptibility
- Wrn
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects. / Wang, Lei; Kaku, Haruki; Huang, Peng; Xu, Kexin; Yang, Kai; Zhang, Jiheng; Li, Ming; Xie, Liping; Wang, Xiaofeng; Sakai, Akiko; Watanabe, Masami; Nasu, Yasutomo; Shimizi, Kenji; Kumon, Hiromi; Naa, Yanqun.
In: Acta Medica Okayama, Vol. 65, No. 5, 2011, p. 315-323.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects
AU - Wang, Lei
AU - Kaku, Haruki
AU - Huang, Peng
AU - Xu, Kexin
AU - Yang, Kai
AU - Zhang, Jiheng
AU - Li, Ming
AU - Xie, Liping
AU - Wang, Xiaofeng
AU - Sakai, Akiko
AU - Watanabe, Masami
AU - Nasu, Yasutomo
AU - Shimizi, Kenji
AU - Kumon, Hiromi
AU - Naa, Yanqun
PY - 2011
Y1 - 2011
N2 - Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare auto-somal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of Pf7?A^LeulO74Phe (rsl801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN LeulO74Phe was genotyped by using a Snapshot assay. The results showed that WRN LeulO74Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR = 0.58, 95%CI: 0.35-0.97, p - 0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <72 yr (OR = 0.27, 95%CI: 0.120.61, p = 0.002) and in patients with localized diseases (OR = 0.36, 95%CI: 0.190.70, p = 0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant LeulO74Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.
AB - Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare auto-somal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of Pf7?A^LeulO74Phe (rsl801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN LeulO74Phe was genotyped by using a Snapshot assay. The results showed that WRN LeulO74Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR = 0.58, 95%CI: 0.35-0.97, p - 0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age <72 yr (OR = 0.27, 95%CI: 0.120.61, p = 0.002) and in patients with localized diseases (OR = 0.36, 95%CI: 0.190.70, p = 0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant LeulO74Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.
KW - Polymorphism
KW - Prostatic neoplasms
KW - Single nucleotide
KW - Susceptibility
KW - Wrn
UR - http://www.scopus.com/inward/record.url?scp=83455186683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=83455186683&partnerID=8YFLogxK
M3 - Article
C2 - 22037268
AN - SCOPUS:83455186683
VL - 65
SP - 315
EP - 323
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 5
ER -