Single nucleotide polymorphism WRN Leu1074Phe is associated with prostate cancer susceptibility in Chinese subjects

Lei Wang, Haruki Kaku, Peng Huang, Kexin Xu, Kai Yang, Jiheng Zhang, Ming Li, Liping Xie, Xiaofeng Wang, Akiko Sakai, Masami Watanabe, Yasutomo Nasu, Kenji Shimizi, Hiromi Kumon, Yanqun Naa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Deficiencies in the human DNA repair gene WRN are the cause of Werner syndrome, a rare auto-somal recessive disorder characterized by premature aging and a predisposition to cancer. This study evaluated the association of Pf7?A^LeulO74Phe (rsl801195), a common missense single nucleotide polymorphism in WRN, with prostate cancer susceptibility in Chinese subjects. One hundred and forty-seven prostate cancer patients and 111 male cancer-free control subjects from 3 university hospitals in China were included. Blood samples were obtained from each subject, and the single nucleotide polymorphism WRN LeulO74Phe was genotyped by using a Snapshot assay. The results showed that WRN LeulO74Phe was associated with the risk of prostate cancer in Chinese men and that the TG/GG genotype displayed a decreased prevalence of prostate cancer compared with the TT genotype (OR = 0.58, 95%CI: 0.35-0.97, p - 0.039). Through stratified analysis, more significant associations were revealed for the TG/GG genotype in the subgroup with diagnosis age < 72 yr (OR = 0.27, 95%CI: 0.120.61, p = 0.002) and in patients with localized diseases (OR = 0.36, 95%CI: 0.190.70, p = 0.003). However, no statistically significant difference was found in the subgroup with age >72 yr or in patients with advanced diseases. We concluded that the genetic variant LeulO74Phe in the DNA repair gene WRN might play a role in the risk of prostate cancer in Chinese subjects.

Original languageEnglish
Pages (from-to)315-323
Number of pages9
JournalActa medica Okayama
Volume65
Issue number5
Publication statusPublished - 2011

Keywords

  • Polymorphism
  • Prostatic neoplasms
  • Single nucleotide
  • Susceptibility
  • Wrn

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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