Two birds with one stone: A method is described for simultaneous optical and electrical recordings of single ion-channel proteins by combining the artificial bilayer technique and single-molecule imaging with a total internal reflection fluorescence microscope. Using this apparatus, interactions between single DNA molecules and single alpha-hemolysin channels are measured (see picture).
- Ion channels
- Single-channel recording
- Single-molecule studies
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Physical and Theoretical Chemistry