Simultaneous Optical and Electrical Recording of Single Molecule Bonding to Single Channel Proteins

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5 Citations (Scopus)

Abstract

Two birds with one stone: A method is described for simultaneous optical and electrical recordings of single ion-channel proteins by combining the artificial bilayer technique and single-molecule imaging with a total internal reflection fluorescence microscope. Using this apparatus, interactions between single DNA molecules and single alpha-hemolysin channels are measured (see picture).

Original languageEnglish
Pages (from-to)3408-3411
Number of pages4
JournalChemPhysChem
Volume11
Issue number16
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

Keywords

  • DNA
  • Ion channels
  • Single-channel recording
  • Single-molecule studies
  • α-hemolysin

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

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