The radioactive multitracer technique was applied to a study on the uptake of trace elements in normal C57BL/6N mice. Comparative uptake behavior of 46Sc, 54Mn, 59Fe, 58Co, 65Zn, 75Se, 88Rb and 88Zr tracers was examined among 11 organs (brain, cardiac muscle, lung, liver, spleen, pancreas, kidneys, bone, muscle, eyeballs and testes) and blood, and evaluated in terms of the 'tissue uptake rate (the radioactivity percentage of injected dose per gram of tissue, %dose/g)'. The multitracer technique revealed reliable data demonstrating characteristic uptake of the 8 trace elements, Sc, Mn, Fe, Co, Zn, Se, Rb and Zr by the brain and other organs, as well as the distinctive feature of the accumulation and retention of each element in the brain.
ASJC Scopus subject areas
- Analytical Chemistry
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis