Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests

Yuko Kawahara, Yoshio Ikeda, Kentaro Deguchi, Tomoko Kurata, Nozomi Hishikawa, Kota Sato, Syoichiro Kono, Taijun Yunoki, Yoshio Omote, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cognitive impairment and affective dysfunction of multiple system atrophy (MSA) and cortical cerebellar atrophy (CCA) have not been simultaneously examined comparing standard test batteries and a sensitive tool to detect subtle cognitive decline in patients. In the present study, we simultaneously examined cognitive and affective ability in MSA with predominant cerebellar ataxia (MSA-C, n = 25), MSA with predominant parkinsonism (MSA-P, n = 8), and CCA (n = 14) patients using computerized touch panel screening tests. Mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), frontal assessment battery (FAB), and Montreal cognitive assessment (MoCA) scores were significantly lower in MSA-C patients than in age-and gender-matched normal controls. One MSA-C patient showed a decrease in the regional cerebral blood flow (rCBF) of the frontal lobe. MSA-P patients showed no such cognitive decline. Only FAB and MoCA scores were significantly lower in the CCA patients. MSA and CCA patients also showed a mild to moderate depressive state. Touch-panel screening tests demonstrated a significant decline of beating devils game in all three disease groups including MSA-P patients, and a significant extension of the flipping cards game only in MSA-C patients. The present study demonstrated different cognitive and affective functions among MSA-C, MSA-P, and CCA patients, and a sensitive screening method for cognitive assessment using touch-panel tests.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalJournal of the Neurological Sciences
Volume351
Issue number1-2
DOIs
Publication statusPublished - Apr 15 2015

Fingerprint

Multiple System Atrophy
Touch
Cognition
Atrophy
Cerebrovascular Circulation
Cerebellar Ataxia
Aptitude
Regional Blood Flow
Parkinsonian Disorders
Frontal Lobe
Dementia

Keywords

  • Affective disorder
  • Cognitive impairment
  • Cortical cerebellar atrophy
  • Multiple system atrophy
  • Regional cerebral blood flow
  • Touch panel screening test

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests. / Kawahara, Yuko; Ikeda, Yoshio; Deguchi, Kentaro; Kurata, Tomoko; Hishikawa, Nozomi; Sato, Kota; Kono, Syoichiro; Yunoki, Taijun; Omote, Yoshio; Yamashita, Toru; Abe, Koji.

In: Journal of the Neurological Sciences, Vol. 351, No. 1-2, 15.04.2015, p. 24-30.

Research output: Contribution to journalArticle

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