Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level

Takeyuki Ohta, Kohsaku Sakaguchi, Akiko Fujiwara, Shin Ichi Fujioka, Yoshiaki Iwasaki, Yasuhiro Makino, Yasuyuki Araki, Yasushi Shiratori

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

This study was conducted to develop a simple surrogate index comprised of routinely available laboratory tests to reflect the histological fibrosis stage. Clinical characteristics and laboratory data from 368 and 249 consecutive patients with chronic hepatitis C, a training cohort and a validation cohort, respectively, were retrospectively evaluated. Platelet (Plt) count and albumin (Alb) level contributed to the discrimination of the respective fibrosis stages. We derived the fibrosis index (FI), FI = 8.0 0.01 × Plt (10 3/μl) - Alb (g/dl), from a multiple regression model. FI significantly correlated with the histological fibrosis stage in both the initial and validation cohort at ρ =0.691 and ρ =0.661, respectively (Spearman's rank correlation coefficient, p<0.0001). The sensitivity and positive predictive value of FI at a cutoff value < 2.10 for predicting fibrosis stage F0-1 were 66.8% and 78.8% in the initial cohort and 68.5% and 63.6% in the validation cohort, respectively. Corresponding values of FI at a cutoff value ≥ 3.30 for the prediction of F4 were 67.7% and 75.0% in the initial cohort and 70.8% and 81.0% in the validation cohort. The fibrosis index comprised of platelet count and albumin level reflected the histological fibrosis stage in patients with chronic hepatitis C. Copyright

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalActa medica Okayama
Volume60
Issue number2
Publication statusPublished - Apr 2006
Externally publishedYes

Keywords

  • Albumin level
  • Chronic hepatitis C
  • Fibrosis index
  • Fibrosis stage
  • Platelet count

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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