Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level

Takeyuki Ohta, Kohsaku Sakaguchi, Akiko Fujiwara, Shin Ichi Fujioka, Yoshiaki Iwasaki, Yasuhiro Makino, Yasuyuki Araki, Yasushi Shiratori

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

This study was conducted to develop a simple surrogate index comprised of routinely available laboratory tests to reflect the histological fibrosis stage. Clinical characteristics and laboratory data from 368 and 249 consecutive patients with chronic hepatitis C, a training cohort and a validation cohort, respectively, were retrospectively evaluated. Platelet (Plt) count and albumin (Alb) level contributed to the discrimination of the respective fibrosis stages. We derived the fibrosis index (FI), FI = 8.0 0.01 × Plt (10 3/μl) - Alb (g/dl), from a multiple regression model. FI significantly correlated with the histological fibrosis stage in both the initial and validation cohort at ρ =0.691 and ρ =0.661, respectively (Spearman's rank correlation coefficient, p

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalActa Medica Okayama
Volume60
Issue number2
Publication statusPublished - Apr 2006

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Chronic Hepatitis C
Platelets
Platelet Count
Serum Albumin
Albumins
Fibrosis
Nonparametric Statistics
Blood Platelets

Keywords

  • Albumin level
  • Chronic hepatitis C
  • Fibrosis index
  • Fibrosis stage
  • Platelet count

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ohta, T., Sakaguchi, K., Fujiwara, A., Fujioka, S. I., Iwasaki, Y., Makino, Y., ... Shiratori, Y. (2006). Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level. Acta Medica Okayama, 60(2), 77-84.

Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level. / Ohta, Takeyuki; Sakaguchi, Kohsaku; Fujiwara, Akiko; Fujioka, Shin Ichi; Iwasaki, Yoshiaki; Makino, Yasuhiro; Araki, Yasuyuki; Shiratori, Yasushi.

In: Acta Medica Okayama, Vol. 60, No. 2, 04.2006, p. 77-84.

Research output: Contribution to journalArticle

Ohta, T, Sakaguchi, K, Fujiwara, A, Fujioka, SI, Iwasaki, Y, Makino, Y, Araki, Y & Shiratori, Y 2006, 'Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level', Acta Medica Okayama, vol. 60, no. 2, pp. 77-84.
Ohta, Takeyuki ; Sakaguchi, Kohsaku ; Fujiwara, Akiko ; Fujioka, Shin Ichi ; Iwasaki, Yoshiaki ; Makino, Yasuhiro ; Araki, Yasuyuki ; Shiratori, Yasushi. / Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level. In: Acta Medica Okayama. 2006 ; Vol. 60, No. 2. pp. 77-84.
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