Simple screening method for judging the complex formation between drug and aluminum (III)

Kanako Miyachi; Masahiro Nakao; Hisashi Kurokawa; Mayu Tomida; Shinichiro Kamino; Kenzo Moriyama; Takako Yamaguchi; Yoshikazu Fujita

doi:10.1248/yakushi.129.1551

Simple screening method for judging the complex formation between drug and aluminum (III)

Kanako Miyachi, Masahiro Nakao, Hisashi Kurokawa, Mayu Tomida, Shinichiro Kamino, Kenzo Moriyama, Takako Yamaguchi, Yoshikazu Fujita

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article

Abstract

We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).

Original language	English
Pages (from-to)	1551-1558
Number of pages	8
Journal	Yakugaku Zasshi
Volume	129
Issue number	12
DOIs	https://doi.org/10.1248/yakushi.129.1551
Publication status	Published - Dec 1 2009

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Keywords

Chromazurol S
Complex formation with aluminum(III)
Erythrosin
Simple screening method
Ternary complex formation

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Cite this

Miyachi, K., Nakao, M., Kurokawa, H., Tomida, M., Kamino, S., Moriyama, K., Yamaguchi, T., & Fujita, Y. (2009). Simple screening method for judging the complex formation between drug and aluminum (III). Yakugaku Zasshi, 129(12), 1551-1558. https://doi.org/10.1248/yakushi.129.1551

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abstract = "We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).",

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AU - Miyachi, Kanako

AU - Nakao, Masahiro

AU - Kurokawa, Hisashi

AU - Tomida, Mayu

AU - Kamino, Shinichiro

AU - Moriyama, Kenzo

AU - Yamaguchi, Takako

AU - Fujita, Yoshikazu

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Access to Document

10.1248/yakushi.129.1551