Abstract
We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).
| Original language | English |
|---|---|
| Pages (from-to) | 1551-1558 |
| Number of pages | 8 |
| Journal | Yakugaku Zasshi |
| Volume | 129 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2009 |
Keywords
- Chromazurol S
- Complex formation with aluminum(III)
- Erythrosin
- Simple screening method
- Ternary complex formation
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
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Cite this
Miyachi, K., Nakao, M., Kurokawa, H., Tomida, M., Kamino, S., Moriyama, K., Yamaguchi, T., & Fujita, Y. (2009). Simple screening method for judging the complex formation between drug and aluminum (III). Yakugaku Zasshi, 129(12), 1551-1558. https://doi.org/10.1248/yakushi.129.1551