Simple screening method for judging the complex formation between drug and aluminum (III)

Kanako Miyachi, Masahiro Nakao, Hisashi Kurokawa, Mayu Tomida, Shinichiro Kamino, Kenzo Moriyama, Takako Yamaguchi, Yoshikazu Fujita

Research output: Contribution to journalArticle

Abstract

We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).

Original languageEnglish
Pages (from-to)1551-1558
Number of pages8
JournalYakugaku Zasshi
Volume129
Issue number12
DOIs
Publication statusPublished - Dec 1 2009

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Keywords

  • Chromazurol S
  • Complex formation with aluminum(III)
  • Erythrosin
  • Simple screening method
  • Ternary complex formation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Miyachi, K., Nakao, M., Kurokawa, H., Tomida, M., Kamino, S., Moriyama, K., Yamaguchi, T., & Fujita, Y. (2009). Simple screening method for judging the complex formation between drug and aluminum (III). Yakugaku Zasshi, 129(12), 1551-1558. https://doi.org/10.1248/yakushi.129.1551