Abstract
We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).
| Original language | English |
|---|---|
| Pages (from-to) | 1551-1558 |
| Number of pages | 8 |
| Journal | Yakugaku Zasshi |
| Volume | 129 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2009 |
| Externally published | Yes |
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Keywords
- Chromazurol S
- Complex formation with aluminum(III)
- Erythrosin
- Simple screening method
- Ternary complex formation
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Cite this
Simple screening method for judging the complex formation between drug and aluminum (III). / Miyachi, Kanako; Nakao, Masahiro; Kurokawa, Hisashi; Tomida, Mayu; Kamino, Shinichiro; Moriyama, Kenzo; Yamaguchi, Takako; Fujita, Yoshikazu.
In: Yakugaku Zasshi, Vol. 129, No. 12, 12.2009, p. 1551-1558.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simple screening method for judging the complex formation between drug and aluminum (III)
AU - Miyachi, Kanako
AU - Nakao, Masahiro
AU - Kurokawa, Hisashi
AU - Tomida, Mayu
AU - Kamino, Shinichiro
AU - Moriyama, Kenzo
AU - Yamaguchi, Takako
AU - Fujita, Yoshikazu
PY - 2009/12
Y1 - 2009/12
N2 - We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).
AB - We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).
KW - Chromazurol S
KW - Complex formation with aluminum(III)
KW - Erythrosin
KW - Simple screening method
KW - Ternary complex formation
UR - http://www.scopus.com/inward/record.url?scp=73449109522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73449109522&partnerID=8YFLogxK
U2 - 10.1248/yakushi.129.1551
DO - 10.1248/yakushi.129.1551
M3 - Article
C2 - 19952536
AN - SCOPUS:73449109522
VL - 129
SP - 1551
EP - 1558
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 12
ER -