Simple, extremely fast, and high-yielding oxidation of thiols to disulfides

Ashraful Alam, Yutaka Takaguchi, Sadao Tsuboi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Results of oxidation of thiols to disulfides with 1,3-dibromo-5,5-dimethyl- hydantoin (DBDMH) are described. A simple addition of 0.20-0.25 mol equivalent of solid DBDMH to thiol in chloroform at room temperature yielded the disulfides in excellent yield. The reaction is extremely fast and gave no other oxidized side products.

Original languageEnglish
Pages (from-to)1329-1333
Number of pages5
JournalSynthetic Communications
Volume35
Issue number10
DOIs
Publication statusPublished - Jun 8 2005

Keywords

  • 1,3-Dibromo-5,5-dimethylhydantoin
  • Disulfides
  • Oxidation of thiols

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Simple, extremely fast, and high-yielding oxidation of thiols to disulfides'. Together they form a unique fingerprint.

  • Cite this