Simple, extremely fast, and high-yielding oxidation of thiols to disulfides

Ashraful Alam; Yutaka Takaguchi; Sadao Tsuboi

doi:10.1081/SCC-200057253

Simple, extremely fast, and high-yielding oxidation of thiols to disulfides

Ashraful Alam, Yutaka Takaguchi, Sadao Tsuboi

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Results of oxidation of thiols to disulfides with 1,3-dibromo-5,5-dimethyl- hydantoin (DBDMH) are described. A simple addition of 0.20-0.25 mol equivalent of solid DBDMH to thiol in chloroform at room temperature yielded the disulfides in excellent yield. The reaction is extremely fast and gave no other oxidized side products.

Original language	English
Pages (from-to)	1329-1333
Number of pages	5
Journal	Synthetic Communications
Volume	35
Issue number	10
DOIs	https://doi.org/10.1081/SCC-200057253
Publication status	Published - Jun 8 2005

Keywords

1,3-Dibromo-5,5-dimethylhydantoin
Disulfides
Oxidation of thiols

ASJC Scopus subject areas

Organic Chemistry

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10.1081/SCC-200057253

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abstract = "Results of oxidation of thiols to disulfides with 1,3-dibromo-5,5-dimethyl- hydantoin (DBDMH) are described. A simple addition of 0.20-0.25 mol equivalent of solid DBDMH to thiol in chloroform at room temperature yielded the disulfides in excellent yield. The reaction is extremely fast and gave no other oxidized side products.",

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author = "Ashraful Alam and Yutaka Takaguchi and Sadao Tsuboi",

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T1 - Simple, extremely fast, and high-yielding oxidation of thiols to disulfides

AU - Alam, Ashraful

AU - Takaguchi, Yutaka

AU - Tsuboi, Sadao

PY - 2005/6/8

Y1 - 2005/6/8

N2 - Results of oxidation of thiols to disulfides with 1,3-dibromo-5,5-dimethyl- hydantoin (DBDMH) are described. A simple addition of 0.20-0.25 mol equivalent of solid DBDMH to thiol in chloroform at room temperature yielded the disulfides in excellent yield. The reaction is extremely fast and gave no other oxidized side products.

AB - Results of oxidation of thiols to disulfides with 1,3-dibromo-5,5-dimethyl- hydantoin (DBDMH) are described. A simple addition of 0.20-0.25 mol equivalent of solid DBDMH to thiol in chloroform at room temperature yielded the disulfides in excellent yield. The reaction is extremely fast and gave no other oxidized side products.

KW - 1,3-Dibromo-5,5-dimethylhydantoin

KW - Disulfides

KW - Oxidation of thiols

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JO - Synthetic Communications

JF - Synthetic Communications

IS - 10

ER -

Simple, extremely fast, and high-yielding oxidation of thiols to disulfides

Abstract

Keywords

ASJC Scopus subject areas

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