Simple, extremely fast, and high-yielding oxidation of thiols to disulfides

Ashraful Alam, Yutaka Takaguchi, Sadao Tsuboi

Research output: Contribution to journalArticle

31 Citations (Scopus)


Results of oxidation of thiols to disulfides with 1,3-dibromo-5,5-dimethyl- hydantoin (DBDMH) are described. A simple addition of 0.20-0.25 mol equivalent of solid DBDMH to thiol in chloroform at room temperature yielded the disulfides in excellent yield. The reaction is extremely fast and gave no other oxidized side products.

Original languageEnglish
Pages (from-to)1329-1333
Number of pages5
JournalSynthetic Communications
Issue number10
Publication statusPublished - 2005



  • 1,3-Dibromo-5,5-dimethylhydantoin
  • Disulfides
  • Oxidation of thiols

ASJC Scopus subject areas

  • Organic Chemistry

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