Silkworm apolipophorin protein inhibits hemolysin gene expression of staphylococcus aureus via binding to cell surface lipoteichoic acids

Yosuke Omae, Yuichi Hanada, Kazuhisa Sekimizu, Chikara Kaito

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Silkworm ApoLp protein binds S. aureus cell surfaces and inhibits hemolysin gene expression. Results: ApoLp protein binds LTA. The ApoLp inhibitory effect was attenuated in an LTA synthetase knockdown mutant. Conclusion: ApoLp protein suppressed S. aureus virulence via LTA binding. Significance: A non-protein macromolecule on the bacterial cell surface functions as a receptor in the bacterial signal transduction pathway.

Original languageEnglish
Pages (from-to)25542-25550
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
Publication statusPublished - Aug 30 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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