Silicosis, then microscopic polyangiitis—antineutrophil cytoplasmic antibodies-associated vasculitis may be work-related disease in patients with silicosis

Yoshito Nishimura, Tomohiro Tsuda, Shinichi Nishina, Akiyoshi Omoto, Mahito Misawa, Hiroki Yabe, Toshihiko Nagao

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A 74-year-old man with silicosis was admitted to the hospital because of prolonged fever. After referral to internal medicine for persistent fever and renal dysfunction, workup revealed antineutrophil cytoplasmic antibodies (ANCA) positivity. He was diagnosed with microscopic polyangiitis (MPA). After treatment with immunosuppressive therapy, his condition improved. Herein, we discuss silica exposure and the risk of ANCA-associated vasculitis (AAV), particularly in terms of work-related diseases. Silica exposure is a notorious risk factor for developing AAV, which is potentially lethal when not identified. When we see a silicosis patient with new-onset prolonged fever and generalized fatigue, AAV should be taken into consideration. This case report provides beneficial information to reliably assess patients at high risk of developing AAV in primary care settings.

Original languageEnglish
Pages (from-to)288-290
Number of pages3
JournalJournal of General and Family Medicine
Volume18
Issue number5
DOIs
Publication statusPublished - Oct 2017

Keywords

  • antineutrophil cytoplasmic antibodies
  • microscopic polyangiitis
  • silicosis
  • work-related disease

ASJC Scopus subject areas

  • Family Practice
  • Geriatrics and Gerontology
  • Internal Medicine

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