Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Yuji Ishii, Harutoshi Kato, Megumu Hatsumura, Takumi Ishida, Noritaka Ariyoshi, Kazuta Oguri

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of liver aldolase B in rats. Hepatic aldolase activity in PenCB-treated rats was significantly reduced to about 50% of that in free- and pair-fed control groups. The reduced aldolase activity following PenCB-treatment was due to the marked suppression of the expression of aldolase B shown by immunoblot analysis after SDS-polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis. The suppression of rat liver aldolase B could be a key biochemical lesion caused by PenCB.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalToxicology
Volume116
Issue number1-3
DOIs
Publication statusPublished - Jan 15 1997
Externally publishedYes

Keywords

  • 3,3',4,4',5-Pentachlorobiphenyl (PCB 126)
  • Aldolase, rat liver
  • Amino acid sequence (peptide mapping)
  • Gluconeogenesis, inhibition
  • Polychlorinated biphenyl (PCB)

ASJC Scopus subject areas

  • Toxicology

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