Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Yuji Ishii; Harutoshi Kato; Megumu Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Kazuta Oguri

doi:10.1016/S0300-483X(96)03543-3

Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl

Yuji Ishii, Harutoshi Kato, Megumu Hatsumura, Takumi Ishida, Noritaka Ariyoshi, Kazuta Oguri

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

A toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of liver aldolase B in rats. Hepatic aldolase activity in PenCB-treated rats was significantly reduced to about 50% of that in free- and pair-fed control groups. The reduced aldolase activity following PenCB-treatment was due to the marked suppression of the expression of aldolase B shown by immunoblot analysis after SDS-polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis. The suppression of rat liver aldolase B could be a key biochemical lesion caused by PenCB.

Original language	English
Pages (from-to)	193-199
Number of pages	7
Journal	Toxicology
Volume	116
Issue number	1-3
DOIs	https://doi.org/10.1016/S0300-483X(96)03543-3
Publication status	Published - Jan 15 1997
Externally published	Yes

Keywords

3,3',4,4',5-Pentachlorobiphenyl (PCB 126)
Aldolase, rat liver
Amino acid sequence (peptide mapping)
Gluconeogenesis, inhibition
Polychlorinated biphenyl (PCB)

ASJC Scopus subject areas

Toxicology

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10.1016/S0300-483X(96)03543-3

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Ishii, Y., Kato, H., Hatsumura, M., Ishida, T., Ariyoshi, N., & Oguri, K. (1997). Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl. Toxicology, 116(1-3), 193-199. https://doi.org/10.1016/S0300-483X(96)03543-3

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abstract = "A toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of liver aldolase B in rats. Hepatic aldolase activity in PenCB-treated rats was significantly reduced to about 50% of that in free- and pair-fed control groups. The reduced aldolase activity following PenCB-treatment was due to the marked suppression of the expression of aldolase B shown by immunoblot analysis after SDS-polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis. The suppression of rat liver aldolase B could be a key biochemical lesion caused by PenCB.",

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author = "Yuji Ishii and Harutoshi Kato and Megumu Hatsumura and Takumi Ishida and Noritaka Ariyoshi and Kazuta Oguri",

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AU - Ishii, Yuji

AU - Kato, Harutoshi

AU - Hatsumura, Megumu

AU - Ishida, Takumi

AU - Ariyoshi, Noritaka

AU - Oguri, Kazuta

PY - 1997/1/15

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