Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma.

Masanori Ikeda, Shoji Natsugoe, Shinichi Ueno, Masamichi Baba, Takashi Aikou

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To identify clinically useful parameters obtainable before treatment of predicting clinical outcomes in patients with esophageal carcinoma. SUMMARY BACKGROUND DATA: Various factors regarding the biologic state of tumors or the nutritional state of patients have been individually reported to correlate with prognosis. Reliable estimates of life expectancy before treatment are important, and consideration needs to be given not only to tumor-related but also to host-related factors in patients with esophageal carcinoma. METHODS: The following clinicopathological factors were retrospectively analyzed in 356 consecutive patients with surgical treatment: sex; age; serum C-reactive protein (CRP); proportion of lymphocytes; body weight changes; serum albumin; clinical TNM staging; tumor location; serum squamous cell-related antigen; serum carcinoembryonic antigen; and histology. Factors related to prognosis were evaluated by using univariate and multivariate analyses. RESULTS: According to univariate analysis, significant differences in survival were found for sex, serum CRP, proportion of lymphocytes, body weight change, serum albumin, serum squamous cell-related antigen, and clinical TNM staging. Multivariate analysis demonstrated that CRP levels (P = 0.0285), body weight change (P = 0.0165), and clinical TNM staging (P = 0.0008) displayed independent correlations to prognosis. When serum CRP elevation, body weight loss, and clinical TNM staging III and IV were scored as a combined index, the total score (prognostic index for esophageal cancer, PIEC) demonstrated a good stratification value for prognosis. Moreover, PIEC was superior to the conventional clinical TNM staging by the likelihood ratio test. CONCLUSIONS: PIEC based on serum CRP, body weight change, and clinical TNM staging before treatment offers a very simple and informative method for predicting the prognosis of patients with esophageal carcinoma.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalAnnals of Surgery
Volume238
Issue number2
Publication statusPublished - Aug 1 2003
Externally publishedYes

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Neoplasm Staging
Body Weight Changes
C-Reactive Protein
Carcinoma
Blood Proteins
Esophageal Neoplasms
Neoplasms
Serum Albumin
Multivariate Analysis
Epithelial Cells
Serum
Lymphocytes
Antigens
Carcinoembryonic Antigen
Biological Factors
Therapeutics
Life Expectancy
Weight Loss
Histology
Body Weight

ASJC Scopus subject areas

  • Surgery

Cite this

Ikeda, M., Natsugoe, S., Ueno, S., Baba, M., & Aikou, T. (2003). Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma. Annals of Surgery, 238(2), 197-202.

Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma. / Ikeda, Masanori; Natsugoe, Shoji; Ueno, Shinichi; Baba, Masamichi; Aikou, Takashi.

In: Annals of Surgery, Vol. 238, No. 2, 01.08.2003, p. 197-202.

Research output: Contribution to journalArticle

Ikeda, M, Natsugoe, S, Ueno, S, Baba, M & Aikou, T 2003, 'Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma.', Annals of Surgery, vol. 238, no. 2, pp. 197-202.
Ikeda, Masanori ; Natsugoe, Shoji ; Ueno, Shinichi ; Baba, Masamichi ; Aikou, Takashi. / Significant host- and tumor-related factors for predicting prognosis in patients with esophageal carcinoma. In: Annals of Surgery. 2003 ; Vol. 238, No. 2. pp. 197-202.
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