Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble fas in patients with viral hepatitis

Naoto Gotohda, Hiromi Iwagaki, Michitaka Ozaki, Taira Kinoshita, Masaru Konishi Toshio Nakagohri, Shinichiro Takahashi, Shinya Saito, Takahito Yagi, Noriaki Tanaka

Research output: Contribution to journalArticle

Abstract

Background/Aims: Liver damage after hepatectomy is still a serious concern. The present study was designed to clarify the relations between liver injury/surgical stress and cytokines after hepatectomy, in patients with viral hepatitis. Methodology: Ten consecutive patients undergoing hepatectomy were studied, all with hepatocellular carcinoma due to viral hepatitis. Blood samples for interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), hepatocyte growth factor (HGF), soluble Fas (sFas), soluble Fas Ligand and soluble tumor necrosis factor receptor (sTNFR) assays were collected before the operation and at the end of the operation. Results: There was a significant and positive correlation between the change in the serum level of HGF and preoperative liver function (ICG-R15). Notably, there were significant correlations between surgical stress and IL-6, HGF and sFas, but not sIL-6R and sTNFR. Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6. Conclusions: There was a close relationship between surgical stress and HGF, IL-6 and sFas after hepatectomy in patients with viral hepatitis. It was useful for the evaluation of surgical stress of hepatectomy to estimate the serum level of HGF, IL-6 and sFas.

Original languageEnglish
Pages (from-to)1400-1403
Number of pages4
JournalHepato-Gastroenterology
Volume55
Issue number85
Publication statusPublished - Jul 2008

Fingerprint

Hepatocyte Growth Factor
Hepatectomy
Hepatitis
Interleukin-6
Serum
Interleukin-6 Receptors
Tumor Necrosis Factor Receptors
Liver
Fas Ligand Protein
Intraoperative Complications
Bilirubin
Albumins
Hepatocellular Carcinoma
Cytokines

Keywords

  • Hepatectomy
  • Hepatocyte growth factor
  • Interleukin-6
  • Soluble fas
  • Surgical stress

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Gotohda, N., Iwagaki, H., Ozaki, M., Kinoshita, T., Nakagohri, M. K. T., Takahashi, S., ... Tanaka, N. (2008). Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble fas in patients with viral hepatitis. Hepato-Gastroenterology, 55(85), 1400-1403.

Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble fas in patients with viral hepatitis. / Gotohda, Naoto; Iwagaki, Hiromi; Ozaki, Michitaka; Kinoshita, Taira; Nakagohri, Masaru Konishi Toshio; Takahashi, Shinichiro; Saito, Shinya; Yagi, Takahito; Tanaka, Noriaki.

In: Hepato-Gastroenterology, Vol. 55, No. 85, 07.2008, p. 1400-1403.

Research output: Contribution to journalArticle

Gotohda, N, Iwagaki, H, Ozaki, M, Kinoshita, T, Nakagohri, MKT, Takahashi, S, Saito, S, Yagi, T & Tanaka, N 2008, 'Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble fas in patients with viral hepatitis', Hepato-Gastroenterology, vol. 55, no. 85, pp. 1400-1403.
Gotohda, Naoto ; Iwagaki, Hiromi ; Ozaki, Michitaka ; Kinoshita, Taira ; Nakagohri, Masaru Konishi Toshio ; Takahashi, Shinichiro ; Saito, Shinya ; Yagi, Takahito ; Tanaka, Noriaki. / Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble fas in patients with viral hepatitis. In: Hepato-Gastroenterology. 2008 ; Vol. 55, No. 85. pp. 1400-1403.
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abstract = "Background/Aims: Liver damage after hepatectomy is still a serious concern. The present study was designed to clarify the relations between liver injury/surgical stress and cytokines after hepatectomy, in patients with viral hepatitis. Methodology: Ten consecutive patients undergoing hepatectomy were studied, all with hepatocellular carcinoma due to viral hepatitis. Blood samples for interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), hepatocyte growth factor (HGF), soluble Fas (sFas), soluble Fas Ligand and soluble tumor necrosis factor receptor (sTNFR) assays were collected before the operation and at the end of the operation. Results: There was a significant and positive correlation between the change in the serum level of HGF and preoperative liver function (ICG-R15). Notably, there were significant correlations between surgical stress and IL-6, HGF and sFas, but not sIL-6R and sTNFR. Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6. Conclusions: There was a close relationship between surgical stress and HGF, IL-6 and sFas after hepatectomy in patients with viral hepatitis. It was useful for the evaluation of surgical stress of hepatectomy to estimate the serum level of HGF, IL-6 and sFas.",
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AU - Nakagohri, Masaru Konishi Toshio

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