TY - JOUR
T1 - Significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble fas in patients with viral hepatitis
AU - Gotohda, Naoto
AU - Iwagaki, Hiromi
AU - Ozaki, Michitaka
AU - Kinoshita, Taira
AU - Nakagohri, Masaru Konishi Toshio
AU - Takahashi, Shinichiro
AU - Saito, Shinya
AU - Yagi, Takahito
AU - Tanaka, Noriaki
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2008/7
Y1 - 2008/7
N2 - Background/Aims: Liver damage after hepatectomy is still a serious concern. The present study was designed to clarify the relations between liver injury/surgical stress and cytokines after hepatectomy, in patients with viral hepatitis. Methodology: Ten consecutive patients undergoing hepatectomy were studied, all with hepatocellular carcinoma due to viral hepatitis. Blood samples for interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), hepatocyte growth factor (HGF), soluble Fas (sFas), soluble Fas Ligand and soluble tumor necrosis factor receptor (sTNFR) assays were collected before the operation and at the end of the operation. Results: There was a significant and positive correlation between the change in the serum level of HGF and preoperative liver function (ICG-R15). Notably, there were significant correlations between surgical stress and IL-6, HGF and sFas, but not sIL-6R and sTNFR. Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6. Conclusions: There was a close relationship between surgical stress and HGF, IL-6 and sFas after hepatectomy in patients with viral hepatitis. It was useful for the evaluation of surgical stress of hepatectomy to estimate the serum level of HGF, IL-6 and sFas.
AB - Background/Aims: Liver damage after hepatectomy is still a serious concern. The present study was designed to clarify the relations between liver injury/surgical stress and cytokines after hepatectomy, in patients with viral hepatitis. Methodology: Ten consecutive patients undergoing hepatectomy were studied, all with hepatocellular carcinoma due to viral hepatitis. Blood samples for interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), hepatocyte growth factor (HGF), soluble Fas (sFas), soluble Fas Ligand and soluble tumor necrosis factor receptor (sTNFR) assays were collected before the operation and at the end of the operation. Results: There was a significant and positive correlation between the change in the serum level of HGF and preoperative liver function (ICG-R15). Notably, there were significant correlations between surgical stress and IL-6, HGF and sFas, but not sIL-6R and sTNFR. Furthermore, there was significant correlation between postoperative liver function (total bilirubin, albumin) and HGF, IL-6. Conclusions: There was a close relationship between surgical stress and HGF, IL-6 and sFas after hepatectomy in patients with viral hepatitis. It was useful for the evaluation of surgical stress of hepatectomy to estimate the serum level of HGF, IL-6 and sFas.
KW - Hepatectomy
KW - Hepatocyte growth factor
KW - Interleukin-6
KW - Soluble fas
KW - Surgical stress
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M3 - Article
C2 - 18795698
AN - SCOPUS:58149389982
VL - 55
SP - 1400
EP - 1403
JO - Hepato-Gastroenterology
JF - Hepato-Gastroenterology
SN - 0172-6390
IS - 85
ER -