Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis - Assessment in chronic hemodialysis patients

Kengo Fukushima Kusano; Kazufumi Nakamura; Hitoshi Kusano; Nobuhiro Nishii; Kimikazu Banba; Tetsuya Ikeda; Katsushi Hashimoto; Mika Yamamoto; Hideki Fujio; Aya Miura; Keiko Ohta; Hiroshi Morita; Hironori Saito; Tetsuro Emori; Yoichi Nakamura; Isao Kusano; Tohru Ohe

doi:10.1253/circj.68.671

Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis - Assessment in chronic hemodialysis patients

Kengo Fukushima Kusano, Kazufumi Nakamura, Hitoshi Kusano, Nobuhiro Nishii, Kimikazu Banba, Tetsuya Ikeda, Katsushi Hashimoto, Mika Yamamoto, Hideki Fujio, Aya Miura, Keiko Ohta, Hiroshi Morita, Hironori Saito, Tetsuro Emori, Yoichi Nakamura, Isao Kusano, Tohru Ohe

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Background: Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported. Methods and Results: The serum MCP-1 concentrations and the intimal-medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP-1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1. Conclusions: An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients.

Original language	English
Pages (from-to)	671-676
Number of pages	6
Journal	Circulation Journal
Volume	68
Issue number	7
DOIs	https://doi.org/10.1253/circj.68.671
Publication status	Published - Jul 2004

Keywords

Atherosclerosis
Cytokine
Hemodialysis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1253/circj.68.671

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Kusano, K. F., Nakamura, K., Kusano, H., Nishii, N., Banba, K., Ikeda, T., Hashimoto, K., Yamamoto, M., Fujio, H., Miura, A., Ohta, K., Morita, H., Saito, H., Emori, T., Nakamura, Y., Kusano, I., & Ohe, T. (2004). Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis - Assessment in chronic hemodialysis patients. Circulation Journal, 68(7), 671-676. https://doi.org/10.1253/circj.68.671

Kusano, KF, Nakamura, K, Kusano, H, Nishii, N, Banba, K, Ikeda, T, Hashimoto, K, Yamamoto, M, Fujio, H, Miura, A, Ohta, K, Morita, H, Saito, H, Emori, T, Nakamura, Y, Kusano, I & Ohe, T 2004, 'Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis - Assessment in chronic hemodialysis patients', Circulation Journal, vol. 68, no. 7, pp. 671-676. https://doi.org/10.1253/circj.68.671

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abstract = "Background: Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported. Methods and Results: The serum MCP-1 concentrations and the intimal-medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP-1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1. Conclusions: An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients.",

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AU - Nishii, Nobuhiro

AU - Banba, Kimikazu

AU - Ikeda, Tetsuya

AU - Hashimoto, Katsushi

AU - Yamamoto, Mika

AU - Fujio, Hideki

AU - Miura, Aya

AU - Ohta, Keiko

AU - Morita, Hiroshi

AU - Saito, Hironori

AU - Emori, Tetsuro

AU - Nakamura, Yoichi

AU - Kusano, Isao

AU - Ohe, Tohru

PY - 2004/7

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N2 - Background: Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported. Methods and Results: The serum MCP-1 concentrations and the intimal-medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP-1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1. Conclusions: An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients.

AB - Background: Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported. Methods and Results: The serum MCP-1 concentrations and the intimal-medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP-1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1. Conclusions: An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients.

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Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis - Assessment in chronic hemodialysis patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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