Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis - Assessment in chronic hemodialysis patients

Kengo Fukushima Kusano, Kazufumi Nakamura, Hitoshi Kusano, Nobuhiro Nishii, Kimikazu Banba, Tetsuya Ikeda, Katsushi Hashimoto, Mika Yamamoto, Hideki Fujio, Aya Miura, Keiko Ohta, Hiroshi Morita, Hironori Saito, Tetsuro Emori, Yoichi Nakamura, Isao Kusano, Tohru Ohe

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Abstract

Background: Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported. Methods and Results: The serum MCP-1 concentrations and the intimal-medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP-1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1. Conclusions: An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients.

Original languageEnglish
Pages (from-to)671-676
Number of pages6
JournalCirculation Journal
Volume68
Issue number7
DOIs
Publication statusPublished - Jul 1 2004

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Keywords

  • Atherosclerosis
  • Cytokine
  • Hemodialysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kusano, K. F., Nakamura, K., Kusano, H., Nishii, N., Banba, K., Ikeda, T., Hashimoto, K., Yamamoto, M., Fujio, H., Miura, A., Ohta, K., Morita, H., Saito, H., Emori, T., Nakamura, Y., Kusano, I., & Ohe, T. (2004). Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis - Assessment in chronic hemodialysis patients. Circulation Journal, 68(7), 671-676. https://doi.org/10.1253/circj.68.671