Significance of PD-L1 expression in tongue cancer development

Saori Yoshida, Hitoshi Nagatsuka, Keisuke Nakano, Yasunao Kogashiwa, Yasuhiro Ebihara, Mitsutake Yano, Masanori Yasuda

Research output: Contribution to journalArticle

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Abstract

Aims: Immunohistochemistry of PD-L1 has been recently established as a surrogate method to predict if immunotherapy targeting PD-L1/PD-1 has a significant effect on suppression of cancers such as lung non-small cell carcinoma, melanoma, and renal cell carcinoma. Here we performed immunohistochemistry for PD-L1 expression in squamous cell carcinoma (SCC) of the tongue to investigate the potential correlation between PD-L1 expression and clinicopathological factors and whether PD-L1 expression would be associated with prognosis. Methods: Tissue microarray cores of paraffin-embedded blocks from 135 cases with surgically resected tongue SCC were immunohistochemically analysed for PD-L1 expression. Results: We observed a positive correlation between PD-L1 expression and tongue SCC pT1 and pT2 tumours, but a negative correlation with pT2, pT3 and pT4 tumours. We also observed a positive correlation with lymph node metastasis. However, no positive correlation was demonstrated between PD-L1 expression and overall survival. Conclusions: PD-L1 tends to be overexpressed at the early stage of tongue SCC, showing a close correlation with initial development of tongue. However, PD-L1 expression may not affect prognosis.

Original languageEnglish
Pages (from-to)1723-1730
Number of pages8
JournalInternational Journal of Medical Sciences
Volume15
Issue number14
DOIs
Publication statusPublished - Oct 20 2018

Fingerprint

Tongue Neoplasms
Tongue
Squamous Cell Carcinoma
Immunohistochemistry
Neoplasms
Renal Cell Carcinoma
Non-Small Cell Lung Carcinoma
Paraffin
Immunotherapy
Melanoma
Lymph Nodes
Neoplasm Metastasis

Keywords

  • Immunohistochemistry
  • Oral pathology
  • PD-L1
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Significance of PD-L1 expression in tongue cancer development. / Yoshida, Saori; Nagatsuka, Hitoshi; Nakano, Keisuke; Kogashiwa, Yasunao; Ebihara, Yasuhiro; Yano, Mitsutake; Yasuda, Masanori.

In: International Journal of Medical Sciences, Vol. 15, No. 14, 20.10.2018, p. 1723-1730.

Research output: Contribution to journalArticle

Yoshida, Saori ; Nagatsuka, Hitoshi ; Nakano, Keisuke ; Kogashiwa, Yasunao ; Ebihara, Yasuhiro ; Yano, Mitsutake ; Yasuda, Masanori. / Significance of PD-L1 expression in tongue cancer development. In: International Journal of Medical Sciences. 2018 ; Vol. 15, No. 14. pp. 1723-1730.
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