Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagus

Ryu Ishihara, Takuya Inoue, Noriya Uedo, Sachiko Yamamoto, Natsuko Kawada, Yoshiki Tsujii, Hiromitsu Kanzaki, Masao Hanafusa, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Hiroyasu Iishi, Masaharu Tatsuta, Yasuhiko Tomita, Shingo Ishiguro

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background and Aim: Although narrow-band imaging (NBI) is used increasingly in clinical situations, the significance of each NBI finding has not been investigated. The primary endpoint of the present study was to identify the significant NBI findings to diagnose esophageal mucosal high-grade neoplasia. Methods: Between August 2007 and January 2009, we detected 59 new superficial esophageal lesions. The video images of NBI were recorded digitally. NBI findings such as brownish dots (dilated intra-epithelial papillary capillary loop [IPCL]), tortuous IPCL, elongated IPCL, caliber change in IPCL, variety in IPCL shapes, demarcation line, brownish epithelium, and protrusion or depression were evaluated using the video images. The association between each NBI finding and diagnosis of mucosal high-grade neoplasia, and intra- and interobserver agreement was evaluated. Results: In univariate analysis, brownish epithelium, brownish dots, tortuous IPCL, variety in IPCL shapes and demarcation line were associated significantly with diagnosis of mucosal high-grade neoplasia. In multivariate analysis, brownish epithelium and brownish dots were confirmed to be independent factors. Odds ratios were 25.5 (95% confidence interval [CI]: 2.4-268) for brownish epithelium and 19.3 (95% CI: 1.8-207.7) for brownish dots. Intraobserver agreement was substantial for brownish epithelium and brownish dots. Interobserver agreement was moderate in brownish epithelium and brownish dots. Conclusions: Brownish epithelium and brownish dots were confirmed to be significant and reproducible NBI findings in the diagnosis of squamous mucosal high-grade neoplasia of the esophagus. Initial assessment of esophageal lesions should be done based on these findings.

Original languageEnglish
Pages (from-to)1410-1415
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume25
Issue number8
DOIs
Publication statusPublished - 2010
Externally publishedYes

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Narrow Band Imaging
Esophagus
Epithelium
Neoplasms
Confidence Intervals
Multivariate Analysis
Odds Ratio

Keywords

  • carcinoma
  • digestive system
  • endoscopy
  • esophageal neoplasms
  • esophagoscopy
  • squamous cell

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagus. / Ishihara, Ryu; Inoue, Takuya; Uedo, Noriya; Yamamoto, Sachiko; Kawada, Natsuko; Tsujii, Yoshiki; Kanzaki, Hiromitsu; Hanafusa, Masao; Hanaoka, Noboru; Takeuchi, Yoji; Higashino, Koji; Iishi, Hiroyasu; Tatsuta, Masaharu; Tomita, Yasuhiko; Ishiguro, Shingo.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 25, No. 8, 2010, p. 1410-1415.

Research output: Contribution to journalArticle

Ishihara, R, Inoue, T, Uedo, N, Yamamoto, S, Kawada, N, Tsujii, Y, Kanzaki, H, Hanafusa, M, Hanaoka, N, Takeuchi, Y, Higashino, K, Iishi, H, Tatsuta, M, Tomita, Y & Ishiguro, S 2010, 'Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagus', Journal of Gastroenterology and Hepatology (Australia), vol. 25, no. 8, pp. 1410-1415. https://doi.org/10.1111/j.1440-1746.2010.06378.x
Ishihara, Ryu ; Inoue, Takuya ; Uedo, Noriya ; Yamamoto, Sachiko ; Kawada, Natsuko ; Tsujii, Yoshiki ; Kanzaki, Hiromitsu ; Hanafusa, Masao ; Hanaoka, Noboru ; Takeuchi, Yoji ; Higashino, Koji ; Iishi, Hiroyasu ; Tatsuta, Masaharu ; Tomita, Yasuhiko ; Ishiguro, Shingo. / Significance of each narrow-band imaging finding in diagnosing squamous mucosal high-grade neoplasia of the esophagus. In: Journal of Gastroenterology and Hepatology (Australia). 2010 ; Vol. 25, No. 8. pp. 1410-1415.
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AU - Kanzaki, Hiromitsu

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