Significance of adrenomedullin under cardiopulmonary bypass in children during surgery for congenital heart disease

Mamoru Takeuchi, Kiyoshi Morita, Tatsuo Iwasaki, Yuichiro Toda, Katsunori Oe, Naoyuki Taga, Masahisa Hirakawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To elucidate the effect of adrenomedullin (AM) on fluid homeostasis under cardiopulmonary bypass (CPB), we investigated the serial changes in plasma AM and other parameters related to fluid homeostasis in 13 children (average age, 28.2 months) with congenital heart disease during cardiac surgery under CPB. Arterial blood and urine samples were collected just after initiation of anesthesia, just before commencement of CPB, 10 min before the end of CPB, 60 min after CPB, and 24 h after operation. Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation. Urine volume increased transiently during CPB, which paralleled changes in AM. Simple regression analysis showed that plasma AM level correlated significantly with urinary vasopressin, urine volume, urinary sodium excretion, and plasma osmolarity. Stepwise regression analysis indicated that urine volume was the most significant determinant of plasma AM levels. Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P < 0.01). Our results suggest that AM plays an important role in fluid homeostasis under CPB in cooperation with other hormones involved in fluid homeostasis.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalActa medica Okayama
Volume55
Issue number4
Publication statusPublished - Dec 1 2001

Keywords

  • Adrenomedullin
  • Brain natriuretic peptide
  • Cardiopulmonary bypass
  • Pediatric cardiac surgery
  • Vasopressin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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