Significance of ACE genotypes and medical treatments in childhood focal glomerulosclerosis

Chikahide Hori, Masahiro Hiraoka, Norishige Yoshikawa, Kazuo Tsuzuki, Yoshiyuki Yoshida, Kazuo Yoshioka, Kazuo Fujisawa, Hurokazu Tsukahara, Yusei Ohshima, Mitsufumi Mayumi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: There is little information on the significance of angiotensin-converting enzyme (ACE) genotypes and medical treatments in children with primary focal segmental glomerulosclerosis (FSGS). Methods: A multicenter retrospective study was performed on the role of ACE genotypes and medical treatments in 43 Japanese children with FSGS (20 males and 23 females), including 17 children who progressed to end-stage renal failure during the mean observation period of 6.9 ± (SD) 5.0 years. Results: The incidence of the D allele of the ACE gene was higher in the whole group of 43 children with FSGS and in a subgroup of 28 steroid-resistant FSGS children (p < 0.05) than in the 130 children of the healthy control group (0.48, 0.48, and 0.33, respectively). ACE genotypes did not affect renal survival in the whole FSGS group nor in the steroid-resistant subgroup. Among the 28 steroid-resistant children, treatment with ciclosporin was effective in delaying the development of end-stage renal failure (p = 0.044), independently of other treatment regimens. Conclusion: The present study of Japanese children with FSGS showed that the D allele of the ACE gene is associated with the development of FSGS, but not associated with the progression of FSGS which was greatly ameliorated with ciclosporin, irrespective of ACE genotypes.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalNephron
Volume88
Issue number4
DOIs
Publication statusPublished - Aug 11 2001
Externally publishedYes

Keywords

  • Angiotensin-converting enzyme
  • Ciclosporin
  • Glomerulosclerosis, focal
  • Nephrotic syndrome
  • Polymorphism (genetics)

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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  • Cite this

    Hori, C., Hiraoka, M., Yoshikawa, N., Tsuzuki, K., Yoshida, Y., Yoshioka, K., Fujisawa, K., Tsukahara, H., Ohshima, Y., & Mayumi, M. (2001). Significance of ACE genotypes and medical treatments in childhood focal glomerulosclerosis. Nephron, 88(4), 313-319. https://doi.org/10.1159/000046014