Significance of 8-hydroxy-2′-deoxyguanosine levels in patients with chronic renal failure

Shigeru Akagi, Yoshio Nagake, Junko Kasahara, Ai Sarai, Takashi Kihara, Hisanori Morimoto, Ai Yano, Kazushi Nakao, Kiyohito Nanba, Haruo Ichikawa, Hirofumi Makino

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35 Citations (Scopus)

Abstract

The aim of this study was to determine the significance of 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is known as a marker of oxidative stress in vivo, in patients with chronic renal failure (CRF). Fifty-one non-dialysed CRF patients (29 men and 22 women; mean ± SD age, 57.8 ± 12.8 years) who were under dietary therapy for at least 6 months were enrolled in the study. Both serum and urinary 8-OHdG levels were measured by using high-sensitive enzyme-linked immunosorbent assay (ELISA) kits. We examined the relationship between 8-OHdG levels and clinical indices in patients with CRF. As a result, the serum 8-OHdG level was strongly correlated with serum levels of urea nitrogen (UN; r = 0.58; P < 0.0001), creatinine (Cr; r = 0.53; P < 0.0001), and β2-microglobulin (β2-MG; r = 0.54; P < 0.0001). Furthermore, the serum 8-OHdG level was inversely correlated with creatinine clearance (Ccr; r = -0.54; P < 0.0001). In contrast, urinary 8-OHdG level was not correlated with any of the clinical parameters. This is the first report of 8-OHdG level determination in patients with CRF. It is suggested that serum 8-OHdG level is not sufficient as a marker of oxidative damage in patients with CRF, and it should be corrected according to the residual renal function to estimate the accurate degree of oxidative stress.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
JournalNephrology
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 2003

Keywords

  • 8-hydroxy-2′-deoxyguanosine
  • Chronic renal failure
  • Oxidative stress

ASJC Scopus subject areas

  • Nephrology

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    Akagi, S., Nagake, Y., Kasahara, J., Sarai, A., Kihara, T., Morimoto, H., Yano, A., Nakao, K., Nanba, K., Ichikawa, H., & Makino, H. (2003). Significance of 8-hydroxy-2′-deoxyguanosine levels in patients with chronic renal failure. Nephrology, 8(4), 192-195. https://doi.org/10.1046/j.1440-1797.2003.00163.x