Signals through CD40 play a critical role in the pathophysiology of Schistosoma mansoni egg antigen-induced allergic rhinitis in mice

Hisashi Hattori, Mitsuhiro Okano, Shin Kariya, Kazunori Nishizaki, Abhay R. Satoskar

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Interaction between CD40 and CD40L is thought to regulate immune responses in several allergic diseases. However, little is known about its in vivo role in the pathophysiology of allergic rhinitis. We sought to determine whether the lack of signals through CD40 affects the pathophysiology of allergic rhinitis using a murine model. Methods: Wild type (WT) and CD40-deficient BALB/c (CD40-/-) mice were sensitized intranasally to Schistosoma mansoni egg antigen (SEA). After repeated sensitization, histamine responsiveness, serum antibody titer including immunoglobunin E (IgE), nasal eosinophilia, and cytokine production by nasal mononuclear cells were determined in each group. Results: Intranasal sensitization with SEA in WT mice elicited a strong Th2 response including SEA-specific IgE production, nasal eosinophilia, and interleukin (IL)-4, and IL-5 production by nasal mononuclear cells after antigen challenge. Production of SEA-specific IgE and IgG1 was abolished in SEA-sensitized CD40-/- mice. These mice showed impaired nasal eosinophilia and displayed markedly reduced histamine-induced nasal hyperresponsiveness as compared with WT mice. Furthermore, reduced production of IL-4 and IL-5 by nasal mononuclear cells was seen in CD40-/- mice. Conclusion: These results show that signals through CD 40 play a critical role in not only IgE production but also pathophysiology of allergic rhinitis such as nasal hyperresponsiveness and nasal eosinophilia.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalAmerican Journal of Rhinology
Volume20
Issue number2
DOIs
Publication statusPublished - Jan 1 2006

ASJC Scopus subject areas

  • Otorhinolaryngology

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