Signaling Factors in a Variety of Cells Derived from Mesenchymal Stem Cells

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.

Original languageEnglish
Pages (from-to)1145-1149
Number of pages5
JournalYakugaku Zasshi
Volume132
Issue number10
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Aminobutyrates
Mesenchymal Stromal Cells
Neurotransmitter Agents
Homeostasis
Central Nervous System
Maintenance
Excitatory Amino Acids
Pituitary Gland
Adrenal Glands
Chondrocytes
Osteoblasts
Glutamic Acid
Pancreas

Keywords

  • chondrocytes
  • glutamate
  • mesenchymal stem cell
  • osteoblasts
  • γ-aminobutyric acid (GABA)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Signaling Factors in a Variety of Cells Derived from Mesenchymal Stem Cells. / Takarada, Takeshi.

In: Yakugaku Zasshi, Vol. 132, No. 10, 2012, p. 1145-1149.

Research output: Contribution to journalArticle

@article{64227e088c5e46faa53c47af089fb64e,
title = "Signaling Factors in a Variety of Cells Derived from Mesenchymal Stem Cells",
abstract = "L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.",
keywords = "chondrocytes, glutamate, mesenchymal stem cell, osteoblasts, γ-aminobutyric acid (GABA)",
author = "Takeshi Takarada",
year = "2012",
doi = "10.1248/yakushi.12-00191",
language = "English",
volume = "132",
pages = "1145--1149",
journal = "Yakugaku Zasshi",
issn = "0031-6903",
publisher = "Pharmaceutical Society of Japan",
number = "10",

}

TY - JOUR

T1 - Signaling Factors in a Variety of Cells Derived from Mesenchymal Stem Cells

AU - Takarada, Takeshi

PY - 2012

Y1 - 2012

N2 - L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.

AB - L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.

KW - chondrocytes

KW - glutamate

KW - mesenchymal stem cell

KW - osteoblasts

KW - γ-aminobutyric acid (GABA)

UR - http://www.scopus.com/inward/record.url?scp=85010120484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010120484&partnerID=8YFLogxK

U2 - 10.1248/yakushi.12-00191

DO - 10.1248/yakushi.12-00191

M3 - Article

AN - SCOPUS:85010120484

VL - 132

SP - 1145

EP - 1149

JO - Yakugaku Zasshi

JF - Yakugaku Zasshi

SN - 0031-6903

IS - 10

ER -