Abstract
L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 1145-1149 |
| Number of pages | 5 |
| Journal | Yakugaku Zasshi |
| Volume | 132 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2012 |
| Externally published | Yes |
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Keywords
- chondrocytes
- glutamate
- mesenchymal stem cell
- osteoblasts
- γ-aminobutyric acid (GABA)
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Cite this
Signaling Factors in a Variety of Cells Derived from Mesenchymal Stem Cells. / Takarada, Takeshi.
In: Yakugaku Zasshi, Vol. 132, No. 10, 2012, p. 1145-1149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Signaling Factors in a Variety of Cells Derived from Mesenchymal Stem Cells
AU - Takarada, Takeshi
PY - 2012
Y1 - 2012
N2 - L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.
AB - L-Glutamate (Glu) and γ-aminobutyric acid (GABA) has been thought to be an excitatory/inhibitory amino acid neurotransmitter in the mammalian central nervous system (CNS). Limited information is available in the literature with regard to an extracellular transmitter role of Glu and GABA in peripheral neuronal and non-neuronal tissues, whereas recent molecular biological analyses including ours give rise to a novel function for Glu and GABA as an autocrine and/or paracrine factor in a variety of cells derived from mesenchymal stem cells, in addition to other peripheral tissues including pancreas, adrenal, and pituitary glands. Emerging evidence suggests that Glu and GABA could play a dual role in mechanisms underlying maintenance of cellular homeostasis as a neurotransmitter in the CNS and as an extracellular signal mediator in peripheral autocrine and/or paracrine tissues. In this review, therefore, we summarized the possible signaling by Glu and GABA as an extracellular signal mediator in mechanisms underlying maintenance of cellular homeostasis in mesenchymal stem cells, osteoblasts and chondrocytes.
KW - chondrocytes
KW - glutamate
KW - mesenchymal stem cell
KW - osteoblasts
KW - γ-aminobutyric acid (GABA)
UR - http://www.scopus.com/inward/record.url?scp=85010120484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010120484&partnerID=8YFLogxK
U2 - 10.1248/yakushi.12-00191
DO - 10.1248/yakushi.12-00191
M3 - Article
AN - SCOPUS:85010120484
VL - 132
SP - 1145
EP - 1149
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 10
ER -