Signal averaged electrocardiography (SAECG) in patients on hemodialysis

Haruo Ichikawa, Yoshio Nagake, Hirofumi Makino

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21 Citations (Scopus)


Cardiovascular diseases are the major cause of mortality in patients on hemodialysis (HD). Recently, signal averaged electrocardiography (SAECG) has been developed to detect venticular late potentials (LP) noninvasively from the body surface for identifying patients at sudden death or ventricular tachycardia. We performed SAECG in 42 patients before and after HD. As a result, postdialysis total filtered QRS duration (FQRS) was significantly increased compared with predialysis FQRS. Postdialysis duration of low amplitude signal under 40 μV in the latter part of QRS (LAS40) tended to increase compared with predialysis LAS40. Before HD, there were no patients with LP and only one patient (2.4%) with abnormal SAECGs. In contrast, after HD, there were three patients (7.1%) with LP and three more patients (7.1%) with abnormal SAECGs. Furthermore, there was a significant correlation between the changes in LAS40 (ΔLAS40) and those in potassium (K) (≃) during HD. We further examined the relation between LAS40 and the concentration og K, by comparing the correlationn coefficient between patients in the high -K group (predialysis K ≤ 5.0 mEq/L;20 patients) and those in the low-K group (predialysis K λ< 5.0 mEq/L; 22 patients). In the low-K group there was no significant correlation between ΔLAS40 and ΔK. However, in the high-K group, there was a significant correlation between ΔLAS40 and ≃. In conclusion, SAECG indices worsened during HD , and an insufficient decrement of serum potassium by HD, is suggetsed to have beev an arrhytmogenic factor in the high-K group.

Original languageEnglish
Pages (from-to)229-243
Number of pages15
JournalJournal of Medicine
Issue number3-4
Publication statusPublished - Nov 11 1997


  • Hemodialysis
  • Signal averaged electrocardiography

ASJC Scopus subject areas

  • Medicine(all)


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