Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: 'real-world evidence' in Japan

Haruhisa Suzuki, Kohei Takizawa, Toshiaki Hirasawa, Yoji Takeuchi, Kenji Ishido, Shu Hoteya, Tomonori Yano, Shinji Tanaka, Masaki Endo, Masahiro Nakagawa, Takashi Toyonaga, Hisashi Doyama, Kingo Hirasawa, Mitsuru Matsuda, Hironori Yamamoto, Mitsuhiro Fujishiro, Satoru Hashimoto, Yuki Maeda, Tsuneo Oyama, Ryuta TakenakaYoshinobu Yamamoto, Yuji Naito, Tomoki Michida, Nozomu Kobayashi, Yoshiro Kawahara, Masaaki Hirano, Mario Jin, Shinichiro Hori, Yasumasa Niwa, Takuto Hikichi, Taichi Shimazu, Hiroyuki Ono, Satoshi Tanabe, Hitoshi Kondo, Hiroyasu Iishi, Motoki Ninomiya, Ichiro Oda

Research output: Contribution to journalReview article

Abstract

Objectives: A Japanese multicenter prospective cohort study examining endoscopic resection (ER) for early gastric cancer (EGC) has been conducted using a Web registry developed to determine the short-term and long-term outcomes based on absolute and expanded indications. We hereby present the short-term outcomes of this study. Methods: All consecutive patients with EGC or suspected EGC undergoing ER at 41 participating institutions between July 2010 and June 2012 were enrolled and prospectively registered into the Web registry. The baseline characteristics were entered before ER, and the short-term outcomes were collected at 6 months following ER. Results: Nine thousand six hundred and sixteen patients with 10,821 lesions underwent ER (endoscopic submucosal dissection [ESD]: 99.4%). The median procedure time was 76 min, and R0 resections were achieved for 91.6% of the lesions. Postoperative bleeding and intraoperative perforation occurred in 4.4% and 2.3% of the patients, respectively. Significant independent factors correlated with a longer procedure time (120 min or longer) were as follows: Tumor size > 20 mm, upperthird location, middle-third location, local recurrent lesion, ulcer findings, gastric tube, male gender, and submucosa. Histopathologically, 10,031 lesions were identified as common-type gastric cancers. The median tumor size was 15 mm. Noncurative resections were diagnosed for 18.3% of the lesions. Additional surgery was performed for 48.6% (824 lesions) of the 1,695 noncurative ER lesions with a possible risk of lymph node (LN) metastasis. Among them, 64 (7.8%) exhibited LN metastasis. Conclusions: This multicenter prospective study showed favorable short-term outcomes for gastric ESD.

Original languageEnglish
Pages (from-to)2397-2408
Number of pages12
JournalGASTROENTEROLOGICAL ENDOSCOPY
Volume61
Issue number10
DOIs
Publication statusPublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Fingerprint Dive into the research topics of 'Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: 'real-world evidence' in Japan'. Together they form a unique fingerprint.

Cite this