Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions

Hirotaka Sakamoto; Ken Ichi Matsuda; Damian G. Zuloaga; Hisayuki Hongu; Etsuko Wada; Keiji Wada; Cynthia L. Jordan; S. Marc Breedlove; Mitsuhiro Kawata

doi:10.1038/nn.2126

Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions

Hirotaka Sakamoto, Ken Ichi Matsuda, Damian G. Zuloaga, Hisayuki Hongu, Etsuko Wada, Keiji Wada, Cynthia L. Jordan, S. Marc Breedlove, Mitsuhiro Kawata

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacological stimulation of spinal GRP receptors restores penile reflexes and ejaculation after castration. GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive dysfunction.

Original language	English
Pages (from-to)	634-636
Number of pages	3
Journal	Nature Neuroscience
Volume	11
Issue number	6
DOIs	https://doi.org/10.1038/nn.2126
Publication status	Published - Jun 2008
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn.2126

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title = "Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions",

abstract = "Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacological stimulation of spinal GRP receptors restores penile reflexes and ejaculation after castration. GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive dysfunction.",

author = "Hirotaka Sakamoto and Matsuda, {Ken Ichi} and Zuloaga, {Damian G.} and Hisayuki Hongu and Etsuko Wada and Keiji Wada and Jordan, {Cynthia L.} and Breedlove, {S. Marc} and Mitsuhiro Kawata",

note = "Funding Information: We thank A. Takara for technical assistance. Supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, Culture and Technology, Japan (H.S., K.-I.M. and M.K.) and US National Institutes of Health grant NS28421 (S.M.B.).",

year = "2008",

month = jun,

doi = "10.1038/nn.2126",

language = "English",

volume = "11",

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AU - Sakamoto, Hirotaka

AU - Matsuda, Ken Ichi

AU - Zuloaga, Damian G.

AU - Hongu, Hisayuki

AU - Wada, Etsuko

AU - Wada, Keiji

AU - Jordan, Cynthia L.

AU - Breedlove, S. Marc

AU - Kawata, Mitsuhiro

N1 - Funding Information: We thank A. Takara for technical assistance. Supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, Culture and Technology, Japan (H.S., K.-I.M. and M.K.) and US National Institutes of Health grant NS28421 (S.M.B.).

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Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions

Abstract

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