Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions

Hirotaka Sakamoto, Ken Ichi Matsuda, Damian G. Zuloaga, Hisayuki Hongu, Etsuko Wada, Keiji Wada, Cynthia L. Jordan, S. Marc Breedlove, Mitsuhiro Kawata

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacological stimulation of spinal GRP receptors restores penile reflexes and ejaculation after castration. GRP offers new avenues for understanding potential therapeutic approaches to masculine reproductive dysfunction.

Original languageEnglish
Pages (from-to)634-636
Number of pages3
JournalNature Neuroscience
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Fingerprint

Gastrin-Releasing Peptide
Ejaculation
Spinal Cord
Bombesin Receptors
Lumbosacral Region
Castration
Androgen Receptors
Axons
Reflex
Pharmacology
Neurons
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions. / Sakamoto, Hirotaka; Matsuda, Ken Ichi; Zuloaga, Damian G.; Hongu, Hisayuki; Wada, Etsuko; Wada, Keiji; Jordan, Cynthia L.; Breedlove, S. Marc; Kawata, Mitsuhiro.

In: Nature Neuroscience, Vol. 11, No. 6, 06.2008, p. 634-636.

Research output: Contribution to journalArticle

Sakamoto, H, Matsuda, KI, Zuloaga, DG, Hongu, H, Wada, E, Wada, K, Jordan, CL, Breedlove, SM & Kawata, M 2008, 'Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions', Nature Neuroscience, vol. 11, no. 6, pp. 634-636. https://doi.org/10.1038/nn.2126
Sakamoto, Hirotaka ; Matsuda, Ken Ichi ; Zuloaga, Damian G. ; Hongu, Hisayuki ; Wada, Etsuko ; Wada, Keiji ; Jordan, Cynthia L. ; Breedlove, S. Marc ; Kawata, Mitsuhiro. / Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions. In: Nature Neuroscience. 2008 ; Vol. 11, No. 6. pp. 634-636.
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