Sexual behavior-associated c-Fos induction in the sagittalis nucleus of the hypothalamus in male rat

Ken Ichi Matsuda, Kei Uchiyama, Hiroko Mori, Sho Maejima, Shohei Yamaguchi, Masaki Tanaka, Shinji Tsukahara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The sagittalis nucleus of the hypothalamus (SGN) is a small nucleus located in the interstitial area between the arcuate and ventromedial nuclei of the hypothalamus in rats. The SGN exhibits male-biased sexual dimorphism and expresses estrogen receptor α and calbindin-D28 K. This suggests a contribution of the SGN to sexually differentiated brain function, but its functional role is unknown. In this study, neuronal activation in the SGN during sexual behavior in male rats was examined by c-Fos immunohistochemistry. The number of c-Fos-immunoreactive (c-Fos-ir) cells was elevated with only exposure to chemosensory cues of estrous females and significantly increased after the first mount. The first intromission and ejaculation did not induce further increases in the number of c-Fos-ir cells in the SGN. These findings suggest that the SGN is involved in regulation of the early phase of male sexual behavior, including motivation.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalNeuroscience Letters
Volume661
DOIs
Publication statusPublished - Nov 20 2017
Externally publishedYes

Fingerprint

Sexual Behavior
Hypothalamus
Calbindins
Arcuate Nucleus of Hypothalamus
Ejaculation
Sex Characteristics
Estrogen Receptors
Cues
Motivation
Immunohistochemistry
Brain

Keywords

  • c-Fos
  • Male sexual behavior
  • Sagittalis nucleus of the hypothalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sexual behavior-associated c-Fos induction in the sagittalis nucleus of the hypothalamus in male rat. / Matsuda, Ken Ichi; Uchiyama, Kei; Mori, Hiroko; Maejima, Sho; Yamaguchi, Shohei; Tanaka, Masaki; Tsukahara, Shinji.

In: Neuroscience Letters, Vol. 661, 20.11.2017, p. 104-107.

Research output: Contribution to journalArticle

Matsuda, Ken Ichi ; Uchiyama, Kei ; Mori, Hiroko ; Maejima, Sho ; Yamaguchi, Shohei ; Tanaka, Masaki ; Tsukahara, Shinji. / Sexual behavior-associated c-Fos induction in the sagittalis nucleus of the hypothalamus in male rat. In: Neuroscience Letters. 2017 ; Vol. 661. pp. 104-107.
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AU - Tanaka, Masaki

AU - Tsukahara, Shinji

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