Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice

K. Watanabe, T. Matsunaga, S. Narimatsu, I. Yamamoto, H. Yoshimura

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Hepatic microsomal oxidation of 11-oxo-Δ8-tetrahydrocannabinol (11-oxo- Δ8-THC) and 9-anthraldehyde (9-AA) to the corresponding carboxylic acids was investigated using six strains of male and female mice (ddN, ddY, C57BL, DBA, C3H and ICR). No significant sex difference was observed in the activity toward 11-oxo-Δ8-THC except for ICR, whereas the activity toward 9-AA was significantly higher in female than in male of ddN, C57BL, DBA and C3H mice. The present study suggests that female specific form(s) of cytochrome P450 may be responsible at least in part for the microsomal oxidation of 9-AA, but not that of 11-oxo-Δ8-THC.

Original languageEnglish
Pages (from-to)373-376
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume78
Issue number3
Publication statusPublished - 1992
Externally publishedYes

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Oxygenases
Dronabinol
Aldehydes
Sex Characteristics
Liver
Inbred DBA Mouse
Inbred C3H Mouse
Carboxylic Acids
Inbred C57BL Mouse
Oxidation
Cytochrome P-450 Enzyme System
9-anthraldehyde
11-oxo-delta(8)-tetrahydrocannabinol

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice. / Watanabe, K.; Matsunaga, T.; Narimatsu, S.; Yamamoto, I.; Yoshimura, H.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 78, No. 3, 1992, p. 373-376.

Research output: Contribution to journalArticle

Watanabe, K, Matsunaga, T, Narimatsu, S, Yamamoto, I & Yoshimura, H 1992, 'Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice', Research Communications in Chemical Pathology and Pharmacology, vol. 78, no. 3, pp. 373-376.
Watanabe, K. ; Matsunaga, T. ; Narimatsu, S. ; Yamamoto, I. ; Yoshimura, H. / Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice. In: Research Communications in Chemical Pathology and Pharmacology. 1992 ; Vol. 78, No. 3. pp. 373-376.
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