Severe interstitial pneumonia induced by paclitaxel in a patient with adenocarcinoma of the lung

Noriyuki Suzaki, Akio Hiraki, Nagio Takigawa, Hiroshi Ueoka, Yasushi Tanimoto, Toshiyuki Kozuki, Masahiro Tabata, Arihiko Kanehiro, Katsuyuki Kiura, Mitsune Tanimoto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A 71-year-old Japanese man with adenocarcinoma of the lung developed interstitial pneumonia after treatment with paclitaxel. The patient had acute chills and fever on the fourth day after the second exposure to paclitaxel, rapidly got worse despite empiric therapies, and developed prolonged respiratory failure requiring mechanical ventilation. Four months later, he died of respiratory failure due to progression of both interstitial pneumonia and lung cancer. This is the first case developing fatal paclitaxel-induced pulmonary toxicity to date. Interstitial pneumonia should be considered one of the possible life-threatening complications during treatment with paclitaxel. Copyright

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalActa medica Okayama
Volume60
Issue number5
Publication statusPublished - Oct 2006

Keywords

  • Adverse effect
  • Interstitial pneumonia
  • Lung cancer
  • Paclitaxel

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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