Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control

Toru Kawada, Shuji Shimizu, Hiromi Yamamoto, Toshiaki Shishido, Atsunori Kamiya, Tadayoshi Miyamoto, Kenji Sunagawa, Masaru Sugimachi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Autonomic neural intervention is a promising tool for modulating the circulatory system thereby treating some cardiovascular diseases. Methods and Results: In 8 pentobarbital-anesthetized cats, it was examined whether the arterial pressure (AP) could be controlled by acupuncture-like hind-limb electrical stimulation (HES). With a 0.5-ms pulse width, HES monotonically reduced AP as the stimulus current increased from 1 to 5 mA, suggesting that the stimulus current could be a primary control variable. In contrast, the depressor effect of HES showed a nadir approximately 10 Hz in the frequency range between 1 and 100 Hz. Dynamic characteristics of the AP response to HES approximated a second-order low-pass filter with dead time (gain: -10.2±1.6 mmHg/mA, natural frequency: 0.040±0.004 Hz, damping ratio 1.80±0.24, dead time: 1.38±0.13 s, mean ± SE). Based on these dynamic characteristics, a servo-controlled HES system was developed. When a target AP value was set at 20 mmHg below the baseline AP, the time required for the AP response to reach 90% of the target level was 38±10 s. The steady-state error between the measured and target AP values was 1.3±0.1 mmHg. Conclusions: Autonomic neural intervention by acupuncture-like HES might provide an additional modality to quantitatively control the circulatory system.

Original languageEnglish
Pages (from-to)851-859
Number of pages9
JournalCirculation Journal
Volume73
Issue number5
DOIs
Publication statusPublished - May 1 2009
Externally publishedYes

Fingerprint

Electric Stimulation
Arterial Pressure
Extremities
Acupuncture
Cardiovascular System
Pentobarbital
Cats
Cardiovascular Diseases

Keywords

  • Proportional-integral controller
  • Transfer function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kawada, T., Shimizu, S., Yamamoto, H., Shishido, T., Kamiya, A., Miyamoto, T., ... Sugimachi, M. (2009). Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control. Circulation Journal, 73(5), 851-859. https://doi.org/10.1253/circj.CJ-08-1058

Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control. / Kawada, Toru; Shimizu, Shuji; Yamamoto, Hiromi; Shishido, Toshiaki; Kamiya, Atsunori; Miyamoto, Tadayoshi; Sunagawa, Kenji; Sugimachi, Masaru.

In: Circulation Journal, Vol. 73, No. 5, 01.05.2009, p. 851-859.

Research output: Contribution to journalArticle

Kawada, T, Shimizu, S, Yamamoto, H, Shishido, T, Kamiya, A, Miyamoto, T, Sunagawa, K & Sugimachi, M 2009, 'Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control', Circulation Journal, vol. 73, no. 5, pp. 851-859. https://doi.org/10.1253/circj.CJ-08-1058
Kawada, Toru ; Shimizu, Shuji ; Yamamoto, Hiromi ; Shishido, Toshiaki ; Kamiya, Atsunori ; Miyamoto, Tadayoshi ; Sunagawa, Kenji ; Sugimachi, Masaru. / Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control. In: Circulation Journal. 2009 ; Vol. 73, No. 5. pp. 851-859.
@article{c35565591b1a451a846b1520f9a5e89f,
title = "Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control",
abstract = "Background: Autonomic neural intervention is a promising tool for modulating the circulatory system thereby treating some cardiovascular diseases. Methods and Results: In 8 pentobarbital-anesthetized cats, it was examined whether the arterial pressure (AP) could be controlled by acupuncture-like hind-limb electrical stimulation (HES). With a 0.5-ms pulse width, HES monotonically reduced AP as the stimulus current increased from 1 to 5 mA, suggesting that the stimulus current could be a primary control variable. In contrast, the depressor effect of HES showed a nadir approximately 10 Hz in the frequency range between 1 and 100 Hz. Dynamic characteristics of the AP response to HES approximated a second-order low-pass filter with dead time (gain: -10.2±1.6 mmHg/mA, natural frequency: 0.040±0.004 Hz, damping ratio 1.80±0.24, dead time: 1.38±0.13 s, mean ± SE). Based on these dynamic characteristics, a servo-controlled HES system was developed. When a target AP value was set at 20 mmHg below the baseline AP, the time required for the AP response to reach 90{\%} of the target level was 38±10 s. The steady-state error between the measured and target AP values was 1.3±0.1 mmHg. Conclusions: Autonomic neural intervention by acupuncture-like HES might provide an additional modality to quantitatively control the circulatory system.",
keywords = "Proportional-integral controller, Transfer function",
author = "Toru Kawada and Shuji Shimizu and Hiromi Yamamoto and Toshiaki Shishido and Atsunori Kamiya and Tadayoshi Miyamoto and Kenji Sunagawa and Masaru Sugimachi",
year = "2009",
month = "5",
day = "1",
doi = "10.1253/circj.CJ-08-1058",
language = "English",
volume = "73",
pages = "851--859",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "5",

}

TY - JOUR

T1 - Servo-controlled hind-limb electrical stimulation for short-term arterial pressure control

AU - Kawada, Toru

AU - Shimizu, Shuji

AU - Yamamoto, Hiromi

AU - Shishido, Toshiaki

AU - Kamiya, Atsunori

AU - Miyamoto, Tadayoshi

AU - Sunagawa, Kenji

AU - Sugimachi, Masaru

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Background: Autonomic neural intervention is a promising tool for modulating the circulatory system thereby treating some cardiovascular diseases. Methods and Results: In 8 pentobarbital-anesthetized cats, it was examined whether the arterial pressure (AP) could be controlled by acupuncture-like hind-limb electrical stimulation (HES). With a 0.5-ms pulse width, HES monotonically reduced AP as the stimulus current increased from 1 to 5 mA, suggesting that the stimulus current could be a primary control variable. In contrast, the depressor effect of HES showed a nadir approximately 10 Hz in the frequency range between 1 and 100 Hz. Dynamic characteristics of the AP response to HES approximated a second-order low-pass filter with dead time (gain: -10.2±1.6 mmHg/mA, natural frequency: 0.040±0.004 Hz, damping ratio 1.80±0.24, dead time: 1.38±0.13 s, mean ± SE). Based on these dynamic characteristics, a servo-controlled HES system was developed. When a target AP value was set at 20 mmHg below the baseline AP, the time required for the AP response to reach 90% of the target level was 38±10 s. The steady-state error between the measured and target AP values was 1.3±0.1 mmHg. Conclusions: Autonomic neural intervention by acupuncture-like HES might provide an additional modality to quantitatively control the circulatory system.

AB - Background: Autonomic neural intervention is a promising tool for modulating the circulatory system thereby treating some cardiovascular diseases. Methods and Results: In 8 pentobarbital-anesthetized cats, it was examined whether the arterial pressure (AP) could be controlled by acupuncture-like hind-limb electrical stimulation (HES). With a 0.5-ms pulse width, HES monotonically reduced AP as the stimulus current increased from 1 to 5 mA, suggesting that the stimulus current could be a primary control variable. In contrast, the depressor effect of HES showed a nadir approximately 10 Hz in the frequency range between 1 and 100 Hz. Dynamic characteristics of the AP response to HES approximated a second-order low-pass filter with dead time (gain: -10.2±1.6 mmHg/mA, natural frequency: 0.040±0.004 Hz, damping ratio 1.80±0.24, dead time: 1.38±0.13 s, mean ± SE). Based on these dynamic characteristics, a servo-controlled HES system was developed. When a target AP value was set at 20 mmHg below the baseline AP, the time required for the AP response to reach 90% of the target level was 38±10 s. The steady-state error between the measured and target AP values was 1.3±0.1 mmHg. Conclusions: Autonomic neural intervention by acupuncture-like HES might provide an additional modality to quantitatively control the circulatory system.

KW - Proportional-integral controller

KW - Transfer function

UR - http://www.scopus.com/inward/record.url?scp=65649099053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649099053&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-08-1058

DO - 10.1253/circj.CJ-08-1058

M3 - Article

C2 - 19293530

AN - SCOPUS:65649099053

VL - 73

SP - 851

EP - 859

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 5

ER -