Serum N-3 polyunsaturated fatty acid levels correlate with the extent of coronary plaques and calcifications in patients with acute myocardial infarction

Masayuki Ueeda, Takenori Doumei, Yoichi Takaya, Ryouko Shinohata, Yusuke Katayama, Nobuhiko Ohnishi, Atsushi Takaishi, Toru Miyoshi, Satoshi Hirohata, Shozo Kusachi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The relationship between serum fatty acid levels and the extent of coronary plaques and calcification was examined in patients with acute myocardial infarction (AMI). Methods and Results: The serum levels of the n-3 polyunsaturated fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and the n-6 polyunsaturated fatty acids (arachidonic acid (AA) and dihomogamma-linolenic acid (DGLA)) were determined using gas chromatography on admission of 95 consecutive patients with their first AMI and 17 controls. Using multidetector-row computed tomography, soft plaques and calcification lesions were scored according to the extent of coronary involvement. Serum logarithmic transformed (log) EPA and logDHA levels were inversely correlated with soft plaque scores (r=-0.546, p

Original languageEnglish
Pages (from-to)1836-1843
Number of pages8
JournalCirculation Journal
Volume72
Issue number11
DOIs
Publication statusPublished - 2008

Fingerprint

Omega-3 Fatty Acids
Eicosapentaenoic Acid
Myocardial Infarction
Serum
alpha-Linolenic Acid
Multidetector Computed Tomography
Docosahexaenoic Acids
Unsaturated Fatty Acids
Arachidonic Acid
Gas Chromatography
Fatty Acids

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Fatty acids
  • Infarction
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Serum N-3 polyunsaturated fatty acid levels correlate with the extent of coronary plaques and calcifications in patients with acute myocardial infarction. / Ueeda, Masayuki; Doumei, Takenori; Takaya, Yoichi; Shinohata, Ryouko; Katayama, Yusuke; Ohnishi, Nobuhiko; Takaishi, Atsushi; Miyoshi, Toru; Hirohata, Satoshi; Kusachi, Shozo.

In: Circulation Journal, Vol. 72, No. 11, 2008, p. 1836-1843.

Research output: Contribution to journalArticle

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AU - Ueeda, Masayuki

AU - Doumei, Takenori

AU - Takaya, Yoichi

AU - Shinohata, Ryouko

AU - Katayama, Yusuke

AU - Ohnishi, Nobuhiko

AU - Takaishi, Atsushi

AU - Miyoshi, Toru

AU - Hirohata, Satoshi

AU - Kusachi, Shozo

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