Serum N-3 polyunsaturated fatty acid levels correlate with the extent of coronary plaques and calcifications in patients with acute myocardial infarction

Masayuki Ueeda, Takenori Doumei, Yoichi Takaya, Ryouko Shinohata, Yusuke Katayama, Nobuhiko Ohnishi, Atsushi Takaishi, Toru Miyoshi, Satoshi Hirohata, Shozo Kusachi

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Abstract

Background: The relationship between serum fatty acid levels and the extent of coronary plaques and calcification was examined in patients with acute myocardial infarction (AMI). Methods and Results: The serum levels of the n-3 polyunsaturated fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and the n-6 polyunsaturated fatty acids (arachidonic acid (AA) and dihomogamma-linolenic acid (DGLA)) were determined using gas chromatography on admission of 95 consecutive patients with their first AMI and 17 controls. Using multidetector-row computed tomography, soft plaques and calcification lesions were scored according to the extent of coronary involvement. Serum logarithmic transformed (log) EPA and logDHA levels were inversely correlated with soft plaque scores (r=-0.546, p

Original languageEnglish
Pages (from-to)1836-1843
Number of pages8
JournalCirculation Journal
Volume72
Issue number11
DOIs
Publication statusPublished - 2008

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Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Fatty acids
  • Infarction
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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